NCT07179887 Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation
| NCT ID | NCT07179887 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Nottingham |
| Condition | Cerebral Autoregulation |
| Study Type | INTERVENTIONAL |
| Enrollment | 45 participants |
| Start Date | 2025-08-27 |
| Primary Completion | 2027-09-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 45 participants in total. It began in 2025-08-27 with a primary completion date of 2027-09-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically. Recent findings have demonsatrated efficacy in a variety of clinical settings. However, the ideal protocol of RIC \[dose\] is unknown. Dynamic Cerebral Autoregulation (dCA) has been shown to increase in response to RIC. The goal of this trial is to study whether an increase in RIC protocol intensity results in a larger effect on biomarkers of vascular health such as dCA. Participants shall: Receive RIC daily, RIC thrice weekly or sham RIC thrice weekly for 6 weeks Visit the School of Medicine at baseline and at 6 weeks for measurement of biomarkers of vascular health including blood pressure, indices od dCA and blood plasma samples
Eligibility Criteria
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study * Participant aged 65 - 85 * Participant is able to perform RIC independently at home Exclusion Criteria: * Active cardiovascular or cerebrovascular disease (acute event within the last 12 months) * Atrial fibrillation or other significant arrhythmias * Peripheral Vascular Disease * Haemostatic disorders * Soft tissue injury or fracture to the upper limb * Pregnant or breast feeding * History or current psychiatric illness * History or current neurological condition (e.g. epilepsy) * Inability to identify temporal window for transcranial doppler ultrasound at screening visit * Any condition or presentation under current investigation that is deemed by the study clinician to exclude the participant from the study. * Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance
Contact & Investigator
Tim England, MBChB PhD
PRINCIPAL INVESTIGATOR
University of Nottingham
Frequently Asked Questions
Who can join the NCT07179887 clinical trial?
This trial is open to participants of all sexes, aged 65 Years or older, up to 85 Years, studying Cerebral Autoregulation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07179887 currently recruiting?
Yes, NCT07179887 is actively recruiting participants. Contact the research team at harry.keevil@nottingham.ac.uk for enrollment information.
Where is the NCT07179887 trial being conducted?
This trial is being conducted at Derby, United Kingdom.
Who is sponsoring the NCT07179887 clinical trial?
NCT07179887 is sponsored by University of Nottingham. The principal investigator is Tim England, MBChB PhD at University of Nottingham. The trial plans to enroll 45 participants.