REmote COnditioning in Out-of-Hospital Cardiac Arrest
Trial Parameters
Brief Summary
Out-of-Hospital Cardiac Arrest remains a major public health problem, resulting in high mortality largely related to multiple organ failure and poor neurological outcomes due to brain anoxia. The pathophysiology of organ dysfunction after resuscitated out-of-hospital cardiac arrest involves ischemia-reperfusion processes. Remote ischemic conditioning is a therapeutic strategy used to protect organs against the detrimental effects of ischemia-reperfusion injury. The objective of the present trial is to determine whether remote ischemic conditioning performed early after out-of-hospital cardiac arrest can decrease mortality, or multiple organ failure and/or severe neurological failure.
Eligibility Criteria
Inclusion Criteria: * Age between 18 and 80 years old * Out-of-hospital cardiac arrest, whatever the initial cardiac rhythm (shockable or non-shockable) or the duration of no-flow and low-flow, * Presence of a witness who may or may not have started cardiopulmonary resuscitation, or patient seen alive in the 30 minutes prior to the cardiac arrest, * Hospitalisation in critical care (intensive care unit or cardiac intensive care unit) for less than 3 hours, * Informed consent obtained from a close relative (exceptionally from the patient himself if his condition permits) or, failing this, use of the emergency procedure by the investigator. Exclusion Criteria: * Traumatic cardiac arrest * Patient on extracorporeal circulatory assistance * Cardiac arrest for which continuation of resuscitation does not appear justified (unavoidable death, terminal stage of an irreversible disease, etc.) * Contraindication of the use of brachial cuff on both arms (arteriovenous fistula, lymphoedema or seve