Regression of Cervical Precancerous Lesions and Associated Risk Factors
Trial Parameters
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Brief Summary
The aim of this study is to assess the extent of histopathological regression of severe cervical precancerous lesions (CIN 2 and CIN 3); evaluate the proportion of patients who experience the normalization of HPV test and cytology finding among those who were treated conservatively and those who underwent conization; and identify predictive parameters associated with regression. Based on this analysis, a model will be proposed to predict the likelihood of lesion regression.
Eligibility Criteria
Inclusion Criteria: 1. squamocolumnar junction fully visualized 2. bioptically verified CIN 2 or CIN 3 3. age ≥ 18 years 4. age ≤ 40 years 5. informed consent Exclusion Criteria: 1. squamocolumnar junction not fully visualized 2. suspicion on glandular lesion 3. suspicion on invasive cancer 4. personal history of CIN 2, 3 or cerv. cancer 5. gravidity 6. HIV positivity 7. immunosuppression 8. impossible photographic documentation