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Recruiting NCT03753412

NCT03753412 Recovery From ICUAW Following Severe Respiratory and Cardiac Failure

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Clinical Trial Summary
NCT ID NCT03753412
Status Recruiting
Phase
Sponsor Barts & The London NHS Trust
Condition Intensive Care Unit Syndrome
Study Type OBSERVATIONAL
Enrollment 100 participants
Start Date 2019-04-09
Primary Completion 2026-09-26

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age N/A
Study Type OBSERVATIONAL

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.

This trial targets 100 participants in total. It began in 2019-04-09 with a primary completion date of 2026-09-26.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

To observe and identify determinants of recovery from intensive care unit-acquired weakness (ICUAW) following a severe cardiorespiratory failure requiring extra-corporeal membrane oxygenation (ECMO). Additionally, to discover the effects of ICUAW on physical function and health-related quality of life (HRQoL) after critical illness. CLEVERER is a clinical observational pilot study.

Eligibility Criteria

Inclusion Criteria: * Above the age of 18 * Adults with severe cardio-respiratory failure requiring ECMO. * Adults who have had personal and professional consultees agree to enrol them in the trial. Exclusion criteria: * Previous Stroke * Neuromuscular disease * Malignancy * Underlying neuromuscular disease * paediatrics

Contact & Investigator

Central Contact

Mark Griffiths, PhD FRCP

✉ Mark.griffiths@bartshealth.nhs.uk

📞 07875999126

Principal Investigator

Mark Griffiths, PhD FRCP

PRINCIPAL INVESTIGATOR

Substantive Employee and primary supervisor to PhD student

Frequently Asked Questions

Who can join the NCT03753412 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, studying Intensive Care Unit Syndrome. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT03753412 currently recruiting?

Yes, NCT03753412 is actively recruiting participants. Contact the research team at Mark.griffiths@bartshealth.nhs.uk for enrollment information.

Where is the NCT03753412 trial being conducted?

This trial is being conducted at London, United Kingdom.

Who is sponsoring the NCT03753412 clinical trial?

NCT03753412 is sponsored by Barts & The London NHS Trust. The principal investigator is Mark Griffiths, PhD FRCP at Substantive Employee and primary supervisor to PhD student. The trial plans to enroll 100 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology