NCT06533176 Real-time Personalized Brain State-dependent TMS After Stroke
| NCT ID | NCT06533176 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Sara Hussain |
| Condition | Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 37 participants |
| Start Date | 2024-08-01 |
| Primary Completion | 2026-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 37 participants in total. It began in 2024-08-01 with a primary completion date of 2026-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and enhance recovery of paretic upper extremity function after stroke. This project will test whether personalized brain state-dependent TMS can activate the residual corticospinal tract better than standard TMS, and evaluate the relationship between this activation and upper extremity motor impairment.
Eligibility Criteria
-Presence of residual upper extremity hemiparesis, defined as any of the following: Fugl Meyer Upper Extremity Score \<66, Wolf Motor Function Test Score \<70, Affected hand performance on the 9-Hole Peg Test \>= 10% worse than unaffected hand, Affected hand pinch, key, or power grip performance \>= 10% worse than unaffected hand, * Occurrence of ischemic or hemorrhagic stroke \>= 6 months before participation * Mini Mental State Exam score \> 24 * Willingness and ability to provide informed consent * No history of neurological disease and/or neurological injury other than stroke * No TMS contraindications, including but not limited to: Cardiac pacemaker, Cochlear implant, Cortical stimulator, Deep brain stimulator, Vagus nerve stimulator, Cervical spine epidural stimulation, Ventriculoperitoneal shunt, Ferromagnetic metallic implants above the level of the seventh cervical vertebra, Seizure in the last 12 months while taking anti-epilepsy medication, History of adverse reactions to TMS or peripheral nerve stimulation, Current, suspected, or planned pregnancy, Any recent changes (within the last month) to medication use \- Presence of residual corticospinal connections innervating an affected upper extremity muscle following stimulation of the lesioned hemisphere (i.e., MEP+), evaluated at rest
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06533176 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06533176 currently recruiting?
Yes, NCT06533176 is actively recruiting participants. Contact the research team at sara-hussain@uiowa.edu for enrollment information.
Where is the NCT06533176 trial being conducted?
This trial is being conducted at Iowa City, United States.
Who is sponsoring the NCT06533176 clinical trial?
NCT06533176 is sponsored by Sara Hussain. The trial plans to enroll 37 participants.
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