NCT06774989 Real-life Pharmacological Monitoring of Encorafenib-Binimetinib in the Treatment of Metastatic Melanoma
| NCT ID | NCT06774989 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Assistance Publique - Hôpitaux de Paris |
| Condition | Melanoma (Skin) |
| Study Type | OBSERVATIONAL |
| Enrollment | 66 participants |
| Start Date | 2025-01-02 |
| Primary Completion | 2028-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 66 participants in total. It began in 2025-01-02 with a primary completion date of 2028-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
In recent years, the prognosis for BRAFV600E-mutant metastatic melanoma has been transformed with targeted therapies combining BRAF and MEK inhibitors (dabrafenib-trametinib and encorafenib-cobimetinib), which have improved progression-free survival and overall survival. However, adverse events are very frequent, and a significant proportion of patients progress secondarily. Several clinical studies have shown that inter-individual variability in plasma exposure to BRAF inhibitors (dabrafenib, vemurafenib) or MEK inhibitors (trametinib) may contribute in part to the occurrence of severe toxicities, and on the efficiency of the treatment. To our knowledge, no data are currently available on the exposure/toxicity relationship for encorafenib and binimetinib. The aim of this study is to assess the association between plasma exposure of encorafenib and binimetinib and the occurrence of dose-limiting toxicity during the first 3 months of treatment. Our secondary objectives are the identification of factors of variability in plasma exposure to encorafenib and binimetinib, the assessment of the exposure-response relationship to treatment (PFS, OS), the evaluation of the influence of the residual plasma concentration of checkpoint inhibiting antibodies (nivolumab, pembrolizumab, ipilimumab) in the first month on the occurrence of dose-limiting toxicity during treatment with encorafenib/binimetinib. Also, the investigators will study the relationship between the kinetics of circulating tumour DNA levels and plasma exposure to encorafenib and binimetinib. Finally, the investigators will assess compliance with treatment. All patients over the age of 18 receiving encorafenib-binimetib for BRAF-mutated metastatic or locally advanced non-operable melanoma, regardless of line, in our 5 centres, will be included. After the patient has been informed and informed that he or she does not wish to be included in the study, an additional blood test will be taken during follow-up visits to the HDJ or specific follow-up consultation for his or her metastatic melanoma, where blood sampling is already planned as part of the treatment, during 1 year. The tubes will be sent to the laboratories for analysis in the usual way as part of routine care. A self-questionnaire will be given to the patient at different follow-up visits. Research data, including clinical, biological and self-questionnaire data, will be collected in the study via a web interface (e-CRF). Follow-up of the population will follow the rhythm of visits scheduled as part of the usual care of patients with melanoma undergoing targeted therapy. the investigators plan a 1-year sampling period, and a 2-year clinical follow-up period for each patient from the time of inclusion. Finally, the investigators plan a period of 1 year to analyze the data and write the article. Statistical analysis will be carried out by the investigating team (R software).
Eligibility Criteria
Inclusion Criteria: Adults ≥ 18 years of age * Histologically confirmed advanced melanoma, stage III/stage IV inoperable (primary cutaneous, mucosal or unknown) * Treatment with encorafenib and/or binimetinib, whatever the line of treatment, for curative purposes. * Affiliated to a social security scheme or beneficiary of such a scheme * informed and non-opposition collected. Exclusion Criteria: \-
Contact & Investigator
Elisa FUNCK-BRETANO, MD, PhD
PRINCIPAL INVESTIGATOR
Department of Oncology-Dermatology, Ambroise Paré Hospital - APHP
Frequently Asked Questions
Who can join the NCT06774989 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Melanoma (Skin). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06774989 currently recruiting?
Yes, NCT06774989 is actively recruiting participants. Contact the research team at elisa.funck-brentano@aphp.fr for enrollment information.
Where is the NCT06774989 trial being conducted?
This trial is being conducted at Boulogne-Billancourt, France.
Who is sponsoring the NCT06774989 clinical trial?
NCT06774989 is sponsored by Assistance Publique - Hôpitaux de Paris. The principal investigator is Elisa FUNCK-BRETANO, MD, PhD at Department of Oncology-Dermatology, Ambroise Paré Hospital - APHP. The trial plans to enroll 66 participants.
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