Radiotherapy or Observation of Liver Metastases in Small Cell Lung Cancer
Trial Parameters
Brief Summary
The aim of this randomized study is to investigate local tumor control,survival outcomes and complications on patients of liver metastasis in small cell lung cancer.
Eligibility Criteria
Inclusion Criteria 1. Informed consent (radiation, medication) before treatment; 2. Age 18 to 70 years old,regardless of gender; 3. Initial SCLC confirmed by histopathological or cytological examination; 4. Metastatic lesions in the distant area: included liver metastasis； 5. Physical status score ECOG: 0 to 2； 6. The expected survival time is more than 3 months; 7. Bone marrow function:hemoglobin(HGB)\>90g/L,platelet(PLT)\>100×109/L,neutrophil cell(WBC)\>1.5×109/L(\*normal value); 8. Liver function:alanine aminotransferase(ALT) and aspertate aminotransferase(AST)\<1.5 times of the upper limit of normal(ULN);Total bilirubin \<1.5ULN; 9. Renal function:Serum creatinine was lower than 1.5ULN,and the endogenous creatinine clearance rate(Ccr) is higher than 55mL/min; 10. Initial treatment (previously did not receive any thoracic radiotherapy or surgery). Exclusion Criteria: 1. patients with history of mental illness; 2. patients combined with other malignancies; 3. Active period of disease