NCT06887829 Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial
| NCT ID | NCT06887829 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Mayo Clinic |
| Condition | Osteoarthritis, Knee |
| Study Type | INTERVENTIONAL |
| Enrollment | 128 participants |
| Start Date | 2025-06-04 |
| Primary Completion | 2026-06-28 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 128 participants in total. It began in 2025-06-04 with a primary completion date of 2026-06-28.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The primary aim of this study is to investigate whether low-dose radiotherapy is an effective treatment to reduce the pain of knee osteoarthritis. A secondary aim is to determine whether patients experience any more measurable side effects than those receiving sham treatments.
Eligibility Criteria
Inclusion Criteria: * • patient's primary care provider is at Mayo Clinic in Rochester, MN * age 50-100 years * ICOAP pain scale A1 at least moderate intensity or B6 at least moderate intensity * diagnosed with primary knee OA ICD-10 codes M17.x o You have not had recurrent episodes of sudden onset of warmth, redness, or swelling of the affected knee * physical exam findings of medial or lateral joint line tenderness on palpation that is in the same location as the knee pain. * absence of primary knee pain in the pes anserine or hamstring or gastrocnemius, quadriceps, or patellar tendons on exam. * radiographic Kellgren-Lawrence grade 2-3 on 4-view knee x-rays taken within the last year ability to complete surveys electronically by email Exclusion Criteria: * • Kellgren-Lawrence grade 1 or 4 * pregnancy or women 54 years and younger with potential for pregnancy (if they or their partner have not had tubal ligation, hysterectomy, or vasectomy) * history of ipsilateral intraarticular knee surgery * use of injected corticosteroids within 3 months or hyaluronans within 6 months or within 1 month if there was no sustained improvement post-injection of either corticosteroid or hyaluronan. * history of trauma to this knee in the last year that clearly caused the pain now present * history of RA, gout, pseudogout, hemarthroses (eg, hemophilic arthropathy) or other inflammatory arthritis involving this knee * history of symptomatic hip OA * history of psychosis, personality disorder, uncontrolled affective disorder * history of fibromyalgia * malignancy requiring active treatment current regular use of opiate analgesics, PRP, or acupuncture for the knees
Contact & Investigator
Stephen P. Merry, M.D.
PRINCIPAL INVESTIGATOR
Mayo Clinic
Frequently Asked Questions
Who can join the NCT06887829 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, up to 100 Years, studying Osteoarthritis, Knee. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06887829 currently recruiting?
Yes, NCT06887829 is actively recruiting participants. Contact the research team at RSTFMSC@mayo.edu for enrollment information.
Where is the NCT06887829 trial being conducted?
This trial is being conducted at Rochester, United States.
Who is sponsoring the NCT06887829 clinical trial?
NCT06887829 is sponsored by Mayo Clinic. The principal investigator is Stephen P. Merry, M.D. at Mayo Clinic. The trial plans to enroll 128 participants.