NCT07787221 QL Block Versus EO Plane Block for Analgesia After Open Nephrectomy
| NCT ID | NCT07787221 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Cairo University |
| Condition | Postoperative Pain |
| Study Type | INTERVENTIONAL |
| Enrollment | 54 participants |
| Start Date | 2026-04-01 |
| Primary Completion | 2027-04-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 54 participants in total. It began in 2026-04-01 with a primary completion date of 2027-04-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This prospective randomized clinical trial aims to compare two ultrasound-guided regional anesthesia techniques, the transmuscular quadratus lumborum (QL) block and the external oblique (EO) plane block, for pain relief after open nephrectomy. Open nephrectomy is a major surgical procedure that can cause significant postoperative pain and may require opioid medications for adequate pain control. Adult patients undergoing open nephrectomy at the National Cancer Institute, Cairo University, who meet the study eligibility criteria will be randomly assigned to receive either a QL block or an EO plane block before surgery. Both techniques will be performed under ultrasound guidance using bupivacaine in addition to standardized general anesthesia and multimodal postoperative analgesia. The main purpose of the study is to determine whether the QL block provides better postoperative analgesia than the EO plane block. The primary outcome will be the total amount of intravenous morphine consumed during the first 24 hours after surgery. Secondary outcomes will include postoperative pain scores, time to first request for rescue analgesia, hemodynamic changes, recovery time, patient satisfaction, and adverse effects related to analgesia or the regional anesthesia techniques. A total of 54 patients will be enrolled and randomly allocated equally between the two treatment groups.
Eligibility Criteria
\*\*Inclusion Criteria:\*\* * Adult patients aged 18 to 65 years. * Patients undergoing open nephrectomy at the National Cancer Institute, Cairo University. * American Society of Anesthesiologists (ASA) physical status II-III. * Body mass index (BMI) greater than 20 kg/m² and less than 35 kg/m². \*\*Exclusion Criteria:\*\* * Patient refusal to participate. * ASA physical status IV. * Age less than 18 years or greater than 65 years. * BMI less than 20 kg/m² or greater than 35 kg/m². * Known allergy or contraindication to any study medication, including local anesthetics or opioids. * History of psychiatric disorders or chronic pain. * Contraindications to regional anesthesia, including local infection at the injection site, pre-existing neuropathy, or coagulopathy. * Severe organ dysfunction, including cardiac dysfunction (ejection fraction \<40%), respiratory dysfunction (FEV1 \<50% of predicted or requirement for home oxygen therapy), hepatic dysfunction (Child-Pugh class C), or renal dysfunction (estimated glomerular filtration rate \<30 mL/min/1.73 m²).
Contact & Investigator
Mona H Abdelhamid, MD
PRINCIPAL INVESTIGATOR
Professor of anesthesia
Frequently Asked Questions
Who can join the NCT07787221 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Postoperative Pain. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07787221 currently recruiting?
Yes, NCT07787221 is actively recruiting participants. Contact the research team at sayed.abed@nci.cu.edu.eg for enrollment information.
Where is the NCT07787221 trial being conducted?
This trial is being conducted at Cairo, Egypt, Cairo, Egypt.
Who is sponsoring the NCT07787221 clinical trial?
NCT07787221 is sponsored by Cairo University. The principal investigator is Mona H Abdelhamid, MD at Professor of anesthesia. The trial plans to enroll 54 participants.