NCT07480655 Pv-aCO₂ Gap-Guided Resuscitation in Adult Polytrauma Patients: A Prospective Randomized Controlled Trial
| NCT ID | NCT07480655 |
| Status | Recruiting |
| Phase | Phase 4 |
| Sponsor | Pakistan Institute of Medical Sciences |
| Condition | Polytrauma |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2026-03-16 |
| Primary Completion | 2026-06-16 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 4 studies follow an already-approved treatment in real-world conditions to monitor long-term safety and effectiveness.
This trial targets 60 participants in total. It began in 2026-03-16 with a primary completion date of 2026-06-16.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
dult patients with multiple traumatic injuries admitted to the ICU from the operating room, emergency department, or hospital wards who meet the study criteria will be included after obtaining informed consent from the patient or their legal guardian. Participants will be randomly divided into two groups: one group will receive treatment guided by the difference between carbon dioxide levels in venous and arterial blood, while the other group will receive treatment based on standard resuscitation parameters commonly used in critical care. As part of routine monitoring, all patients will have a central venous catheter and an arterial line inserted to measure blood parameters. Blood samples from both lines will be taken shortly after ICU admission and at regular intervals during the first three days. These samples will be analyzed using a bedside blood gas machine, and the results will be compared between the two groups to determine whether monitoring the difference in carbon dioxide levels between venous and arterial blood improves patient outcomes compared with standard care.
Eligibility Criteria
Inclusion Criteria: * Either Gender * Poly-trauma patients ○ Both penetrating and blunt trauma * Both surgical and non-surgical * Shock States Exclusion Criteria: * Any Chest trauma * Patients with Obstructive and restrictive lung disease * Obstructive sleep apnea * Septic shock * Pregnant patients * Patients who will require readmission within 48 h after step-down from the ICU. * Patients who will need extra-corporeal membrane oxygenation support
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07480655 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 70 Years, studying Polytrauma. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT07480655 trial and what does that mean for participants?
Phase 4 studies are conducted after a treatment has been approved. They monitor long-term safety and real-world effectiveness in a broader patient population.
Is NCT07480655 currently recruiting?
Yes, NCT07480655 is actively recruiting participants. Contact the research team at haroonanwar22@gmail.com for enrollment information.
Where is the NCT07480655 trial being conducted?
This trial is being conducted at Islamabad, Pakistan.
Who is sponsoring the NCT07480655 clinical trial?
NCT07480655 is sponsored by Pakistan Institute of Medical Sciences. The trial plans to enroll 60 participants.