NCT07352215 PRP Plus Fractional CO₂ Laser for Acne Scars
| NCT ID | NCT07352215 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Gujranwala medical college District Headquarters Hospital, Gujranwala |
| Condition | Post-Acne Atrophic Scars |
| Study Type | INTERVENTIONAL |
| Enrollment | 70 participants |
| Start Date | 2025-10-31 |
| Primary Completion | 2026-01-12 |
Trial Parameters
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Brief Summary
This randomized controlled trial aims to evaluate whether adding platelet-rich plasma (PRP) to fractional CO₂ laser resurfacing improves the treatment of moderate-to-severe acne scars compared with laser alone. Seventy adults aged 18-40 years will be recruited from the Dermatology Department of Gujranwala Medical College Teaching Hospital. Participants will be randomly assigned to receive either fractional CO₂ laser combined with topical PRP or fractional CO₂ laser alone, with three treatment sessions delivered four weeks apart. The primary outcome is the change in acne scar severity measured using the Goodman and Baron Quantitative Acne Scar Scale. Secondary outcomes include redness, edema, pain scores, and patient satisfaction assessed using Likert and numeric rating scales. The study is single-blinded, with patients unaware of treatment allocation. PRP will be prepared using a standardized double-spin centrifugation process. Data will be analyzed using appropriate statistical tests with a significance level of p \< 0.05. The study aims to determine whether PRP enhances laser efficacy, reduces side effects, and improves patient-reported outcomes.
Eligibility Criteria
Inclusion Criteria:Adults aged 18 to 40 years Male and female participants Fitzpatrick skin types I to V Presence of moderate-to-severe acne scars Willing to undergo 3 treatment sessions and follow-up visits Able to provide informed consent - Exclusion Criteria:Use of topical anti-acne medications in the past 1 month History of keloid formation or hypertrophic scarring Active acne or active skin inflammation at treatment area Diabetes mellitus Photosensitive disorders (e.g., lupus, dermatomyositis) Melasma Active infections (e.g., Herpes simplex) Recent laser resurfacing or similar procedures Outdoor workers with high sun exposure Vitiligo Pregnancy or breastfeeding Bleeding disorders or anticoagulant therapy Unrealistic expectations or inability to comply with follow-up \-