NCT07277309 Promoting Recovery After Brain Injury Using Focused Ultrasound
| NCT ID | NCT07277309 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Massachusetts General Hospital |
| Condition | Consciousness Disorders |
| Study Type | INTERVENTIONAL |
| Enrollment | 36 participants |
| Start Date | 2026-05-26 |
| Primary Completion | 2029-07 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 36 participants in total. It began in 2026-05-26 with a primary completion date of 2029-07.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this project aims to (1) determine neurobehavioral responses to low-intensity focused ultrasound (LIFUP) in patients with disorders of consciousness (DoC) following brain injury, (2) determine neurophysiologic (EEG) responses to LIFUP in patients with DoC and (3) identify and evaluate ethical perspectives of patient representatives (family members and surrogate decision-makers) surrounding investigation of therapeutic neuromodulation technologies such as LIFUP in patients with DoC.
Eligibility Criteria
Inclusion Criteria: * Brain injury resulting in DoC diagnosis, following international guidelines * At least 18 years of age * Legally authorized representative (surrogate) available to consent Exclusion Criteria: * History of neurological disorder other than the brain injury * Metal implant or other condition precluding MRI * Manifest continuous spontaneous movement (which would prevent safe/successful MRI) * Participation in concurrent therapeutic study * Pregnancy
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07277309 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 79 Years, studying Consciousness Disorders. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07277309 currently recruiting?
Yes, NCT07277309 is actively recruiting participants. Contact the research team at michael.young@mgh.harvard.edu for enrollment information.
Where is the NCT07277309 trial being conducted?
This trial is being conducted at Boston, United States, Cambridge, United States.
Who is sponsoring the NCT07277309 clinical trial?
NCT07277309 is sponsored by Massachusetts General Hospital. The trial plans to enroll 36 participants.