NCT07479277 Progel Platinum for Air Leak Reduction After VATS Lobectomy for NSCLC
| NCT ID | NCT07479277 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Fondazione del Piemonte per l'Oncologia |
| Condition | Non-Small Cell Lung Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 160 participants |
| Start Date | 2026-02-27 |
| Primary Completion | 2027-02-27 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 160 participants in total. It began in 2026-02-27 with a primary completion date of 2027-02-27.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This multicenter randomized trial evaluates whether routine use of Progel Platinum surgical sealant on stapled fissure lines during VATS upper or lower lobectomy for NSCLC reduces pleural drainage duration compared with standard stapling alone. Secondary objectives include postoperative length of stay, incidence and duration of postoperative air leaks, residual pleural space, safety outcomes, and hospitalization costs.
Eligibility Criteria
Inclusion Criteria: * Age ≥18 years * Written informed consent * Planned VATS upper or lower lobectomy for NSCLC * Minimally invasive thoracoscopic approach * Middle lobectomy excluded Exclusion Criteria: * Induction radiochemotherapy or chemo-immunotherapy * Severe COPD: GOLD 3 or higher * Sleeve resection or extended resection involving other lobes/chest wall/pericardium, etc. * Albumin intolerance/allergy * Renal insufficiency * Redo surgery * Use of sealants/adhesives other than the study approach * Expected extensive pleural adhesions
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07479277 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 99 Years, studying Non-Small Cell Lung Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07479277 currently recruiting?
Yes, NCT07479277 is actively recruiting participants. Contact the research team at andrea.droghetti@ircc.it for enrollment information.
Where is the NCT07479277 trial being conducted?
This trial is being conducted at Candiolo, Italy, Bolzano, Italy, Florence, Italy, Milan, Italy and 2 additional locations.
Who is sponsoring the NCT07479277 clinical trial?
NCT07479277 is sponsored by Fondazione del Piemonte per l'Oncologia. The trial plans to enroll 160 participants.
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