Trial Parameters
Brief Summary
A randomized, double-blind, placebo-controlled clinical trial will be performed to assess the efficacy of a probiotic containing Lactobacillus reuteri in improving post-surgical wound healing after impacted tooth extractions. The Primary aim is to evaluate the efficacy of L. reuteri in improving post-extractive healing. The Secondary aim is to evaluate the efficacy of L. reuteri in association with an antibiotic therapy (amoxicillin) in reducing the incidence and severity of antibiotic-associated gastro-intestinal symptoms.
Eligibility Criteria
Inclusion Criteria: * need for impacted tooth extractions * over age 18 * ability to understand and to sign an informed consent form Exclusion Criteria: * allergy to penicillin * contraindications to oral surgery * treatment with immunosuppressive agents or immunocompromised * treatment with amino-bisphosphonate and anti-angiogenetic medications * irradiation to head and neck area * uncontrolled diabetes * renal failure * drug and alcohol addiction * psychiatric disorders