NCT07281040 Preparatory Work for a Trial of Adjuncts to Diuretic Treatment in Patients Hospitalised With Heart Failure: Addressing Uncertainties and Building Consensus
| NCT ID | NCT07281040 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Hull University Teaching Hospitals NHS Trust |
| Condition | Heart Failure |
| Study Type | OBSERVATIONAL |
| Enrollment | 10 participants |
| Start Date | 2025-07-02 |
| Primary Completion | 2026-10-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 10 participants in total. It began in 2025-07-02 with a primary completion date of 2026-10-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Aims and Objectives 1. Choose which adjunctive therapies, at what dose, and for how long 2. Choose the dose(s) of IV furosemide to be used as the comparator 3. Choose primary and secondary outcomes 4. Estimate recruitment and engage sites for a future trial Work package 2a methods overview 1. An online survey of clinicians (doctors, nurses and pharmacists) assessing potential ability to recruit and the acceptability of each adjunct and willingness to support a trial. 2. Evidence generated (survey and reviews) will be considered by an expert panel (N=20-25) including expert clinicians and allied health professionals who care for people with HF using a modified Delphi approach. The panel will make recommendations on all aspects of the trial design. 3. A patient and carer panel of people with a recent hospitalisation (\<6 months) for HF will provide recommendations on trial endpoints. The patient-and-carer advisory group (PCAG) will also input into these discussions.
Eligibility Criteria
Inclusion Criteria: 1. Recent hospitalisation with heart failure (\<6 months) or carer for a person with a recent hospitalisation with heart failure. 2. Able to participate in online group discussions in English Exclusion Criteria: 1\. Unable to participate in online group discussions in English
Contact & Investigator
Joe Cuthbert, MBBS MD
PRINCIPAL INVESTIGATOR
Wolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Cottingham Road, Kingston-Upon-Hull, HU6 7RX
Frequently Asked Questions
Who can join the NCT07281040 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Heart Failure. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07281040 currently recruiting?
Yes, NCT07281040 is actively recruiting participants. Contact the research team at joe.cuthbert@hyms.ac.uk for enrollment information.
Where is the NCT07281040 trial being conducted?
This trial is being conducted at Hull, United Kingdom.
Who is sponsoring the NCT07281040 clinical trial?
NCT07281040 is sponsored by Hull University Teaching Hospitals NHS Trust. The principal investigator is Joe Cuthbert, MBBS MD at Wolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Cottingham Road, Kingston-Upon-Hull, HU6 7RX. The trial plans to enroll 10 participants.
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