NCT07316426 Preoptimisation in Ventral Hernia Surgery
| NCT ID | NCT07316426 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Umeå University |
| Condition | Hernia |
| Study Type | INTERVENTIONAL |
| Enrollment | 130 participants |
| Start Date | 2025-09-22 |
| Primary Completion | 2027-09-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 130 participants in total. It began in 2025-09-22 with a primary completion date of 2027-09-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The study is a multicentre, single-blinded, randomised controlled trial. Ventral hernia patients with an aperture width between four and eight centimetres are randomised to either participation in a multimodal preoptimisation programme, including interventions to increase physical activity, promote weight loss, and optimise the treatment of comorbidities, or to surgery without structured preoptimisation. The primary endpoint is complications at three months postoperatively. During surgery, biopsies of skin, muscle, and fascia will be collected, along with pre- and postoperative blood samples, to analyse the molecular effects of preoptimisation, particularly in relation to collagen metabolism.
Eligibility Criteria
Inclusion Criteria: * Patients with a ventral hernia with a defect width of at least 4 cm. * Symptom burden related to the hernia sufficient to justify surgical intervention. * Age ≥ 18 years. Exclusion Criteria: * Expected survival of less than three years. * Inability to comprehend oral and written information or to provide informed consent. * Acute complication of the hernia requiring emergency surgical intervention. * General condition characterised by severe limitations in physical functional capacity.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07316426 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Hernia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07316426 currently recruiting?
Yes, NCT07316426 is actively recruiting participants. Contact the research team at gunnar.nordqvist@umu.se for enrollment information.
Where is the NCT07316426 trial being conducted?
This trial is being conducted at Gällivare, Sweden, Luleå, Sweden, Lycksele, Sweden, Skellefteå, Sweden and 1 additional location.
Who is sponsoring the NCT07316426 clinical trial?
NCT07316426 is sponsored by Umeå University. The trial plans to enroll 130 participants.