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Recruiting Phase 2, Phase 3 NCT04209868

Preoperative Paravertebral Block in Cancer Surgery of the Lung

Trial Parameters

Condition Thoracic Neoplasm
Sponsor Guy's and St Thomas' NHS Foundation Trust
Study Type INTERVENTIONAL
Phase Phase 2, Phase 3
Enrollment 100
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2019-02-01
Completion 2024-12
Interventions
Levo-Bupivacaine Hydrochloride (HCl) 0.5 % in 20mL Injection0.9% Sodium Chloride 20mL Injection

Brief Summary

The investigators aim to determine whether ultrasound-guided preemptive paravertebral blockade (PVB) local anaesthetic (pre-PVB LA), administered in addition to the post-operative PVB (post-PVB) local anaesthetic (LA) infusion, reduces acute postoperative pain, opioid requirement, chronic pain, and improves surgical recovery, in thoracoscopic surgery for lung cancer.

Eligibility Criteria

Inclusion Criteria: * Elective radical primary lung cancer VATS surgery for single lobectomy * American Society of Anesthesiology (ASA) I-III * Age ≥18 Exclusion Criteria: * Planned open thoracotomy, wedge resection, bilobectomy, pneumonectomy, chest wall resection or total pleurectomy * Local anaesthetic or opioid allergy * Coagulation disorders * Inability to comply with study questionnaire completion * Pre-existing pain in chest area or pre-existing pain conditions * Local infection/tumour at proposed PVB site * Previous lung surgery * Planned surgery within 3 months of the primary lung resection

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