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Recruiting NCT05673304

NCT05673304 Preoperative Boost Associated With Neoadjuvant Chemotherapy in Luminal B Breast Cancer

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Clinical Trial Summary
NCT ID NCT05673304
Status Recruiting
Phase
Sponsor IRCCS Azienda Ospedaliero-Universitaria di Bologna
Condition Breast Cancer
Study Type INTERVENTIONAL
Enrollment 30 participants
Start Date 2023-05-24
Primary Completion 2027-12-31

Eligibility & Interventions

Sex Female only
Min Age 18 Years
Max Age N/A
Study Type INTERVENTIONAL
Interventions
SBRT anticipated boost

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.

This trial targets 30 participants in total. It began in 2023-05-24 with a primary completion date of 2027-12-31.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

IBISCO TRIAL is a phase II trial aimed to demonstrate the improvement of pathological complete response (pCR) in Luminal B breast cancer (BC) patients treated with stereotactic radiation therapy (SBRT) as an anticipated boost associated with neoadjuvant chemotherapy (NAC). As a secondary objective, histochemical and molecular analysis of the tumour and the inflammatory microenvironment will be performed.

Eligibility Criteria

Inclusion Criteria: * Luminal B-like BC, cT1-2 * Indication for neoadjuvant chemotherapy Exclusion Criteria: * Pregnancy * Breast feeding * Patient not available for follow up

Contact & Investigator

Central Contact

Alice Zamagni, MD

✉ alice.zamagni4@unibo.it

📞 +39 0512143564

Principal Investigator

Alessio G Morganti, MD, PhD

PRINCIPAL INVESTIGATOR

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Frequently Asked Questions

Who can join the NCT05673304 clinical trial?

This trial is open to female participants only, aged 18 Years or older, studying Breast Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT05673304 currently recruiting?

Yes, NCT05673304 is actively recruiting participants. Contact the research team at alice.zamagni4@unibo.it for enrollment information.

Where is the NCT05673304 trial being conducted?

This trial is being conducted at Bologna, Italy.

Who is sponsoring the NCT05673304 clinical trial?

NCT05673304 is sponsored by IRCCS Azienda Ospedaliero-Universitaria di Bologna. The principal investigator is Alessio G Morganti, MD, PhD at IRCCS Azienda Ospedaliero-Universitaria di Bologna. The trial plans to enroll 30 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology