NCT07033741 Predictors and Process Moderators of EMDR Therapy for Depressive Symptoms
| NCT ID | NCT07033741 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Turin, Italy |
| Condition | Depression, Anxiety |
| Study Type | OBSERVATIONAL |
| Enrollment | 40 participants |
| Start Date | 2025-01-08 |
| Primary Completion | 2027-12 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 40 participants in total. It began in 2025-01-08 with a primary completion date of 2027-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to evaluate which factors influence the effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) therapy for depressive symptoms in real-world settings in Italy. The main questions the study seeks to answer are: * Which key factors influence EMDR outcomes in terms of mediators, moderators, and predictors of its effectiveness for depressive symptoms? * Do lower levels of individual psychological functioning at baseline, including high co-occurrence of personality domains and pathogenic personal beliefs, predict the effects of EMDR in treating depressive symptoms? * Are baseline psychological comorbidities (anxiety, dissociation, post-traumatic symptoms, emotional dysregulation, and sleep difficulties) and the quality of the therapeutic alliance related to the effectiveness of EMDR therapy for depressive symptoms? Participants will be both therapists and patients. * Eligible therapists must be certified members of the EMDR Italian National Association to ensure adherence to established standards in the practice of EMDR therapy and consistency in therapeutic delivery. Therapists will identify patients from their routine clinical practice who meet the study inclusion criteria and facilitate their enrollment. * Eligible patients must meet the following criteria: 1. Being 18 years of age or older. 2. being able to give informed consent. 3. presenting clinically significant symptoms in at least one of the following domains: anxiety, depression, dissociative, or post-traumatic stress symptoms. Individuals presenting with severe neurological impairment or other severe psychiatric conditions were excluded. Researchers will combine data from multiple N-of-1 trials (N-of-1 or single-subject clinical trials studies) using a Bayesian multilevel random-effects meta-analysis and meta-regression to generate robust estimates of treatment efficacy.
Eligibility Criteria
Participants: Therapist * Inclusion Criteria: * certified members of the Italian Eye Movement Desensitization and Reprocessing (EMDR) Association * Exclusion Criteria: * inability or unwillingness to comply with study protocols or schedules Patient * Inclusion Criteria: * age 18 years or older * capacity of providing informed consent * presenting with clinically significant symptoms in at least one of the following domains: anxiety, depression, post-traumatic stress symptoms, or dissociative symptoms. * Exclusion Criteria: * history of psychotic symptoms or schizophrenia * dementia * severe personality disorders * a serious, unstable medical condition * acute suicidality that needs hospitalization.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07033741 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Depression, Anxiety. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07033741 currently recruiting?
Yes, NCT07033741 is actively recruiting participants. Contact the research team at francesca.cotardo@unito.it for enrollment information.
Where is the NCT07033741 trial being conducted?
This trial is being conducted at Turin, Italy.
Who is sponsoring the NCT07033741 clinical trial?
NCT07033741 is sponsored by University of Turin, Italy. The trial plans to enroll 40 participants.
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.