Depression trials address major depressive disorder (MDD), treatment-resistant depression (TRD), and postpartum depression with a growing toolkit that extends beyond conventional SSRIs/SNRIs. The rapid approval of ketamine/esketamine for TRD has sparked interest in NMDA receptor modulators, while psychedelic-assisted therapy (psilocybin, MDMA) trials represent a paradigm shift in psychiatric research.
Active trials investigate rapid-acting antidepressants (ketamine analogs), neuroactive steroids, transcranial magnetic stimulation (TMS) protocols, psychedelic-assisted psychotherapy, digital therapeutics, and precision psychiatry approaches using biomarkers or genetic testing to predict treatment response.
Depression trials typically require a minimum MADRS or HAMD score at baseline; TRD trials usually require failure of at least 2 prior adequate antidepressant courses.
Frequently Asked Questions — depression anxiety Clinical Trials
How many clinical trials are currently recruiting for depression anxiety?
ClinicalMetric currently tracks 2 actively recruiting clinical trials for depression anxiety, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 2. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for depression anxiety?
depression anxiety research spans multiple clinical trial phases. Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a depression anxiety clinical trial?
Eligibility criteria for depression anxiety trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Top Sponsors
Centre Hospitalier Universitaire de Saint Etienne 1 trial
Washington University School of Medicine 1 trial
Recruiting Clinical Trials
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional.
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Last Reviewed: April 2026 ·
Data Methodology