NCT07607080 Predicting High-Flow Nasal Cannula Failure in Acute Hypoxemic Respiratory Failure Using Metabolomics and Clinical Data
| NCT ID | NCT07607080 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Hospital del Mar Research Institute (IMIM) |
| Condition | Acute Hypoxemic Respiratory Failure |
| Study Type | OBSERVATIONAL |
| Enrollment | 300 participants |
| Start Date | 2026-06-04 |
| Primary Completion | 2029-05 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 300 participants in total. It began in 2026-06-04 with a primary completion date of 2029-05.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this observational study is to determine whether metabolomic profiles combined with clinical data can predict high-flow nasal cannula (HFNC) failure and help optimize respiratory support in adult patients with acute hypoxemic respiratory failure (AHRF). The main questions it aims to answer are: Can metabolomic biomarkers identify patients at higher risk of HFNC failure? Does combining metabolomic and clinical data improve the prediction of respiratory support escalation and clinical outcomes? Participants will: Receive standard HFNC treatment according to clinical practice. Undergo collection of clinical, physiological, and laboratory data. Provide blood samples for metabolomic analysis during respiratory support.
Eligibility Criteria
Inclusion Criteria: * Adult patients (≥18 years old). * Admission to the intensive care unit (ICU) with acute hypoxemic respiratory failure (AHRF). * Treatment with high-flow nasal cannula (HFNC) as the initial respiratory support strategy. * Inclusion within the first 24 hours after HFNC initiation. * Provision of informed consent by the patient or legally authorized representative. Exclusion Criteria: * Age \<18 years. * Active do-not-resuscitate (DNR) orders or limitation of therapeutic effort. * Refusal or inability to provide informed consent. * Previous invasive mechanical ventilation before study inclusion.
Contact & Investigator
Francisco José Parrilla-Gómez, MD, Phd
PRINCIPAL INVESTIGATOR
Hospital del Mar
Frequently Asked Questions
Who can join the NCT07607080 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Acute Hypoxemic Respiratory Failure. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07607080 currently recruiting?
Yes, NCT07607080 is actively recruiting participants. Contact the research team at fparilla@hmar.cat for enrollment information.
Where is the NCT07607080 trial being conducted?
This trial is being conducted at Barcelona, Spain.
Who is sponsoring the NCT07607080 clinical trial?
NCT07607080 is sponsored by Hospital del Mar Research Institute (IMIM). The principal investigator is Francisco José Parrilla-Gómez, MD, Phd at Hospital del Mar. The trial plans to enroll 300 participants.