Precision Medicine Trial Based on Molecular Matching Therapy for Patients With Standard Treatment Exhaustion
Trial Parameters
Brief Summary
The main purpose of this study is to explore the feasibility of selecting treatment plans based on genomic variations guided by MTB in patients with advanced refractory solid tumors.
Eligibility Criteria
Inclusion Criteria: 1. Recurrent or metastatic malignant solid tumors diagnosed by histology or cytology; 2. ECOG score 0-4 (3-4 points only for patients with tumor burden); 3. Those who fail or cannot tolerate standard treatment, or those who refuse standard treatment; 4. At least one measurable lesion that meets the RECIST 1.1 standard; 5. Expected survival period ≥ 3 months; 6. Age ≥ 18 years old; 7. Tumor tissue blocks with sufficient formalin fixed paraffin embedding (FFPE), or chest or ascites with cancer cells detected during treatment (not less than 200ml), or excised metastatic lymph nodes, or peripheral blood (approximately 5m1) can be used for genetic testing; 8. Understand and voluntarily participate in this study, and sign the informed consent form. Exclusion Criteria: 1. Patients who have actively undergone or are currently participating in clinical trials for treatment; 2. Serious or uncontrolled medical diseases (i.e. uncontrolled diabetes, chronic kidney disease, chron