A Study of SHR-7367 With Anti-tumor Agents in Patients With Solid Tumors
Trial Parameters
Brief Summary
This study aims to evaluate the safety and preliminary efficacy of SHR-7367 in combination with antineoplastic agents in subjects with advanced solid tumors, and to determine the maximum tolerated dose (MTD) and the recommended Phase II dose (RP2D).
Eligibility Criteria
Inclusion Criteria: 1. Be able and willing to provide a written informed consent. 2. Age 18-75 years old (inclusive) at the time of signing the informed consent form. 3. ECOG performance status 0-1. 4. Life expectancy is not less than 12 weeks. 5. At least one measurable lesion per RECIST v1.1. 6. Adequate organ and marrow function as defined by the protocol. Exclusion Criteria: 1. Presence of uncontrollable psychiatric illness and other conditions such as known alcoholism, drug or substance abuse, criminal detention, etc., that affect the completion of the study procedures. 2. Known hypersensitivity to any component of SHR-7367; History of severe allergic reactions to other monoclonal antibodies/fusion protein drugs; Known history of severe hypersensitivity to antineoplastic agents in combination. 3. Subjects who are participating in other clinical studies or whose first dose is less than 4 weeks from the end of the previous clinical study (last dose). 4. Surgery or chemotherapy withi