NCT07165444 Potassium-Competitive Acid Blocker Versus Proton Pump Inhibitor as A Part of Bismuth Based Quadruple Therapy for Treatment of Helicobacter Pylori Infection
| NCT ID | NCT07165444 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Tanta University |
| Condition | Potassium-Competitive Acid Blocker |
| Study Type | INTERVENTIONAL |
| Enrollment | 320 participants |
| Start Date | 2025-09-11 |
| Primary Completion | 2026-02-01 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
This study aims to compare the eradication rate, safety, and patient adherence between potassium-competitive acid blockers (P-CABs) and proton pump inhibitor-based bismuth quadruple therapy in patients with Helicobacter pylori infection.
Eligibility Criteria
Inclusion Criteria: * Adults aged ≥18 years. * Both sexes. * Confirmed Helicobacter pylori infection by stool antigen (3rd-gen ELISA) or urea breath test (UBT). * No prior eradication therapy. Exclusion Criteria: * Prior Helicobacter pylori treatment. * Use of antibiotics, proton pump inhibitor, or bismuth in the prior 4 weeks. * Gastric surgery history. * Major organ failure. * Pregnancy or lactation. * Known allergy to study drugs.