NCT06540976 Posterior Cingulate Cortex and Executive Control of Episodic Memory
| NCT ID | NCT06540976 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Pennsylvania |
| Condition | Episodic Memory |
| Study Type | INTERVENTIONAL |
| Enrollment | 130 participants |
| Start Date | 2023-01-18 |
| Primary Completion | 2027-03-02 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 130 participants in total. It began in 2023-01-18 with a primary completion date of 2027-03-02.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This project will use intracranial recordings and stimulation of the human brain to understand the unique contributions of the posterior cingulate cortex (PCC) to episodic memory behavior. The goal is to test how distinct subregions of the PCC differentially contribute to memory-based decisions (e.g., have I seen this picture before?). The ability to perform invasive studies of the human brain is through routine clinical monitoring of brain activity which occurs during the neurosurgical treatment of epilepsy. However, this project only focuses on the basic science of PCC and memory behavior. Specifically, the investigators will use single-0cell and population measures of brain activity to test a new theory of PCC function which focuses on the executive processes needed to support memory retrieval and memory-based decisions. By studying the PCC, a convergence zone of memory and executive brain systems, progress can be made in elucidating how the failure to successfully leverage past experiences in daily behavior can occur as a common symptom of both neurodegenerative disease (e.g., Alzheimer's disease) and multiple psychiatric conditions (e.g., schizophrenia) implicating PCC dysfunction.
Eligibility Criteria
Inclusion Criteria: * All participants are patients undergoing invasive brain monitoring for epilepsy and will be asked to consent to participation in this basic science protocol (which is focused on the patient group but is not focused on the study of epilepsy). Exclusion Criteria: * Individuals not undergoing invasive brain monitoring for epilepsy. * Individuals outside of the age range (18-50 yrs). * Individuals with cognitive impairment or intellectual difficulty.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06540976 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 50 Years, studying Episodic Memory. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06540976 currently recruiting?
Yes, NCT06540976 is actively recruiting participants. Contact the research team at Ilaina.Edelstein@Pennmedicine.upenn.edu for enrollment information.
Where is the NCT06540976 trial being conducted?
This trial is being conducted at Philadelphia, United States.
Who is sponsoring the NCT06540976 clinical trial?
NCT06540976 is sponsored by University of Pennsylvania. The trial plans to enroll 130 participants.