Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort
Trial Parameters
Eligibility Fast-Check
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Brief Summary
Enrolling of 150 female patients of fertile age diagnosed with PCOS, insulin resistance, infertility, or mitochondrial disease, and the same number of age- and sex-matched controls are planned. During the research biomarkers already with mitochondrial dysfunction in the scientific literature and common mtDNA abnormalities (deletions, point mutations, copy number changes, etc.) are examined.
Eligibility Criteria
Inclusion Criteria: * Presence of polycystic ovary syndrome (PCOS) or insulin resistance (IR) associated with other multisystemic phenotypes, mitochondrial dysfunction * history of infertility associated with other multisystemic phenotypes, mitochondrial dysfunction * a known history of mitochondrial dysfunction and PCOS and/or IR * general health is good and there is no serious general medical condition that would prevent participation would make participation highly risky Exclusion Criteria: * poor cooperation * refusal to participate in the study