NCT05166343 POHCA Resuscitation: Evaluation of IM Epinephrine
| NCT ID | NCT05166343 |
| Status | Recruiting |
| Phase | Phase 2, Phase 3 |
| Sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
| Condition | Pediatric Out-of-Hospital Cardiac Arrest |
| Study Type | INTERVENTIONAL |
| Enrollment | 284 participants |
| Start Date | 2024-01-08 |
| Primary Completion | 2028-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.
This trial targets 284 participants in total. It began in 2024-01-08 with a primary completion date of 2028-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a pragmatic, two-arm, open-label, prospective stepped-wedge cluster quasi randomized control trial (SW-CRCT) looking to evaluate early intramuscular (IM) epinephrine in the management of pediatric out-of-hospital cardiac arrest (POHCA).
Eligibility Criteria
Inclusion Criteria: * Children aged 1 day to and including 17 years experiencing an out-of-hospital cardiac arrest (OHCA) * Must be receiving at least 1 minute of CPR by trained first responders (police, fire, or paramedic services) Exclusion Criteria: \- Children who experience OHCA due to an obvious traumatic event.
Contact & Investigator
Janice Tijssen, MD MSc
PRINCIPAL INVESTIGATOR
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Frequently Asked Questions
Who can join the NCT05166343 clinical trial?
This trial is open to participants of all sexes, aged 1 Day or older, up to 17 Years, studying Pediatric Out-of-Hospital Cardiac Arrest. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT05166343 trial and what does that mean for participants?
Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.
Is NCT05166343 currently recruiting?
Yes, NCT05166343 is actively recruiting participants. Contact the research team at maysaa.assaf@lhsc.on.ca for enrollment information.
Where is the NCT05166343 trial being conducted?
This trial is being conducted at London, Canada.
Who is sponsoring the NCT05166343 clinical trial?
NCT05166343 is sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's. The principal investigator is Janice Tijssen, MD MSc at London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's. The trial plans to enroll 284 participants.