NCT06950606 Pneumatic Leg Compression and Norepinephrine Requirements in Patients Having Non-cardiac Surgery
| NCT ID | NCT06950606 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Universitätsklinikum Hamburg-Eppendorf |
| Condition | Hypotension During Surgery |
| Study Type | INTERVENTIONAL |
| Enrollment | 238 participants |
| Start Date | 2025-05-19 |
| Primary Completion | 2025-09 |
Trial Parameters
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Brief Summary
The PLANE trial is a randomized, single-center trial investigating whether pneumatic leg compression reduces the amount of norepinephrine needed to keep MAP above 65mmHg compared to routine care without PLC in patients having non-cardiac surgery under general anesthesia
Eligibility Criteria
Inclusion Criteria: Consenting patients ≥45 years scheduled for elective non-cardiac surgery under general anesthesia that is expected to last ≥60 minutes Exclusion Criteria: Patients with the following exclusion criteria: * Surgery in which pneumatic calve compression is indicated according to ERAS guidelines * Surgery which interferes with the installation or correct function of PLC * Sepsis (according to current Sepsis-3 definition) * Pregnancy * Congestive heart failure NYHA III/IV * American Society of Anesthesiologists (ASA) physical status classification V or VI * Interference of PLC and patient positioning (e.g.; extreme Trendelenburg positioning, lithotomy positioning) * Contraindications for the use of PLC according to the German guideline13 (e.g., extensive thrombophlebitis, thrombosis or suspected thrombosis of the lower limbs, erysipelas, acute phlegmon, limb compartment syndrome, severe uncontrolled arterial hypertension, lymphatic drainage disorder proximal to PLC, exten