NCT05727761 Pioglitazone-Metformin Combination Treatment for High Risk Oral Preneoplasia
| NCT ID | NCT05727761 |
| Status | Recruiting |
| Phase | Phase 2 |
| Sponsor | University of Minnesota |
| Condition | Oral Leukoplakia |
| Study Type | INTERVENTIONAL |
| Enrollment | 36 participants |
| Start Date | 2025-01-01 |
| Primary Completion | 2027-07-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.
This trial targets 36 participants in total. It began in 2025-01-01 with a primary completion date of 2027-07-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a Phase IIa oral cavity leukoplakia study of pioglitazone 15mg and metformin 500mg BID for 12 weeks. The primary objective is to determine the clinical and histologic changes of leukoplakia from baseline following a 12 week course of twice daily pioglitazone-metformin. Outcomes are defined as are a reduction of the leukoplakia grade in \> 50% of treated participants and a partial or complete clinical response defined as 50% or greater reduction in the sum of measured targeted lesions. In addition, participants who show clinical and histologic improvement should correlate with a significant reduction of Ki-67 proliferative indices in lesions of these participants as compared to baseline.
Eligibility Criteria
Inclusion Criteria: * Biopsy proven hyperplasia in high risk anatomic areas (floor of mouth, mobile tongue, oropharynx). Hyperplasia or dysplasia of any grade in any erythroplakia lesion. Mild, moderate or severe dysplasia within the lesion at any site of the oral cavity or oropharynx. * Must have objective evidence of oral leukoplakia that is measurable in 2 dimensions per RECIST. The lesion(s) may be clinically characterized by leukoplakia, erythroplakia, erythro/leukoplakia. Lesions may be located in the oral cavity or oropharynx. However, the index lesion must be located in an anatomic site accessible by punch biopsy and be a minimum of 4mm x 8 mm to permit a 4mm punch biopsy. * Age 18 years or older at the time of consent. * Evidence of adequate organ function within 14 days prior to Day 1 * Able to comply with treatment (i.e. able to swallow a tablet whole, not crushed) and complete a 12 week course of twice daily medication as required by this study in the opinion of the treating investigator. * Body mass index (BMI) is ≥ 18.5. * Sexually active persons of child-bearing potential agrees to use adequate contraception (a hormonal method that has been in continual use for a minimum of 3 months prior to the study screening visit, a barrier method, or abstinence) for the duration of study participation. * Provides voluntary written consent prior to the performance of any research related activity. Exclusion Criteria: * Pregnant or breastfeeding or planning to become pregnant. * A concurrent diagnosis of Type I or Type II diabetes that is being treated with insulin or an antidiabetic agent. Participants whose Type II diabetes is controlled with diet and/or exercise alone are eligible provided they meet all other eligibility criteria. * Participant is taking another investigational agent (not approved by the FDA for any indication). * A history of allergic reactions attributed to compounds of similar chemical or biologic composition to ACTOplus Met, pioglitazone or metformin. * Any contraindication to biopsy - this study requires a 4 mm punch biopsy of a lesion and of nearby normal tissue prior to treatment and at the end of the 12 week treatment period. * History of bladder cancer, including in situ bladder cancer. * History of invasive cancer (other than non-melanoma skin cancer or cervical cancer in situ) active within 18 months prior to the baseline study visit. (Participants who have a history of cancer that was curatively treated without evidence of recurrence in the 18 months prior to the baseline study visit are considered eligible).
Contact & Investigator
Frank Ondrey
PRINCIPAL INVESTIGATOR
University of Minnesota
Frequently Asked Questions
Who can join the NCT05727761 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Oral Leukoplakia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT05727761 trial and what does that mean for participants?
Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.
Is NCT05727761 currently recruiting?
Yes, NCT05727761 is actively recruiting participants. Contact the research team at knier003@umn.edu for enrollment information.
Where is the NCT05727761 trial being conducted?
This trial is being conducted at Minneapolis, United States, Saint Paul, United States.
Who is sponsoring the NCT05727761 clinical trial?
NCT05727761 is sponsored by University of Minnesota. The principal investigator is Frank Ondrey at University of Minnesota. The trial plans to enroll 36 participants.