NCT07276087 Physical and Psychosocial Parameters in Takayasu Arteritis and Behçet's Disease: A Comparative Study With Healthy Controls
| NCT ID | NCT07276087 |
| Status | Recruiting |
| Phase | — |
| Sponsor | ÖZLEM NUR TOK YAMAN |
| Condition | Takayasu Arteritis |
| Study Type | OBSERVATIONAL |
| Enrollment | 30 participants |
| Start Date | 2025-09-11 |
| Primary Completion | 2025-12-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 30 participants in total. It began in 2025-09-11 with a primary completion date of 2025-12-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Systemic vasculitis refers to a group of rare diseases characterized by inflammation of blood vessel walls, which may cause ischemia and structural damage in various organs. Among large-vessel vasculitides, Takayasu arteritis primarily affects the aorta and its main branches, whereas Behçet's disease is a variable vessel vasculitis involving arteries and veins of all sizes. Both conditions can lead to multisystemic involvement and significantly impact physical and psychosocial health. This observational, case-control study aims to compare multiple physical and psychosocial parameters among individuals with Takayasu arteritis, Behçet's disease, and healthy controls. Assessments will include respiratory and peripheral muscle strength, functional status, exercise capacity, body composition, quality of life, illness perception, and psychological well-being. Measurements will be conducted using standardized clinical tests (such as maximal inspiratory and expiratory pressures, handgrip and limb strength dynamometry, squat test, and six-minute walk test) and validated questionnaires (Health Assessment Questionnaire (HAQ), the Short Form-36 Health Survey (SF-36), the EuroQol 5-Dimension 5-Level Questionnaire (EQ-5D-5L), and the Visual Analogue Scale (VAS)). The study seeks to identify differences between groups and provide a comprehensive understanding of how systemic inflammation in Takayasu arteritis and Behçet's disease affects physical performance, quality of life, and psychosocial health. These findings may help guide physiotherapy, rehabilitation, and multidisciplinary management strategies for patients with systemic vasculitis.
Eligibility Criteria
Inclusion Criteria: Inclusion Criteria (Takayasu Arteritis Group): * Age 18 years or older. * Diagnosis of Takayasu arteritis according to the American College of Rheumatology (ACR) classification criteria. * Voluntary participation with written informed consent. Inclusion Criteria (Behçet's Disease Group): * Age 18 years or older. * Diagnosis of Behçet's disease according to the International Study Group for Behçet's Disease criteria. * Voluntary participation with written informed consent. Inclusion Criteria (Healthy Control Group): * Age 18 years or older. * No history of systemic, rheumatologic, or chronic inflammatory disease. * Voluntary participation with written informed consent. Exclusion Criteria: Exclusion Criteria (Patient Groups - Takayasu Arteritis and Behçet's Disease): * Pregnancy. * Presence of psychiatric disorder or ongoing psychiatric treatment. * Cognitive impairment that may interfere with participation. * Presence of neurological disease (e.g., hemiplegia, Parkinson's disease, multiple sclerosis, vertigo, epilepsy, etc.). * History of any surgical operation within the past year. * Coexisting rheumatic disease other than Takayasu arteritis or Behçet's disease. Exclusion Criteria (Healthy Control Group): * Pregnancy. * Presence of psychiatric disorder or ongoing psychiatric treatment. * Cognitive impairment that may interfere with participation. * Presence of neurological disease (e.g., hemiplegia, Parkinson's disease, multiple sclerosis, vertigo, epilepsy, etc.). * History of any surgical operation within the past year. * History of rheumatologic or chronic inflammatory disease.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07276087 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Takayasu Arteritis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07276087 currently recruiting?
Yes, NCT07276087 is actively recruiting participants. Contact the research team at ozlem.tok@alanya.edu.tr for enrollment information.
Where is the NCT07276087 trial being conducted?
This trial is being conducted at Denizli, Turkey (Türkiye).
Who is sponsoring the NCT07276087 clinical trial?
NCT07276087 is sponsored by ÖZLEM NUR TOK YAMAN. The trial plans to enroll 30 participants.