NCT05680558 Photopheresis in Early-stage Mycosis Fungoides
| NCT ID | NCT05680558 |
| Status | Recruiting |
| Phase | Phase 2 |
| Sponsor | Columbia University |
| Condition | Cutaneous T Cell Lymphoma |
| Study Type | INTERVENTIONAL |
| Enrollment | 74 participants |
| Start Date | 2021-05-08 |
| Primary Completion | 2027-03 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.
This trial targets 74 participants in total. It began in 2021-05-08 with a primary completion date of 2027-03.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to determine whether photopheresis therapy can be used to improve the clinical course of early stage cutaneous T-cell lymphoma (CTCL). Currently, photopheresis is performed as a palliative treatment for late stage CTCL. However, recent studies have demonstrated that patients with early stage CTCL may have markers in their blood which were previously observed primarily in late stage disease, such as clonal T cell populations. Considering these findings, the study aims to investigate whether photopheresis therapy may be used earlier in the disease course to produce a clinical response.
Eligibility Criteria
Inclusion Criteria: 1. Who are male or female, over the age of 18 and \<40 kg body weight with adequate veins to provide intravenous access. 2. Who are willing to adhere to the protocol and sign an Informed Patient Consent Document 3. Must not be on any other investigational device/drug treatment. 4. Who have the diagnosis of Mycosis Fungoides (MF) including a skin biopsy consistent with MF (atypical epidermotropic or folliculocentric T-cells) with appropriate staging as IA, IB or IIA: T1 or T2 (patches or plaques) with measurable lesions. 5. With IA stage must demonstrate a minor blood abnormality by morphology/laboratory assessment. 6. With IIA stage - clinically significant nodes (1.5 cm) must have lymph node biopsy showing dermatopathic nodes or no involvement. 7. Must be willing and able to discontinue concomitant medications for MF. Subjects currently taking the following drugs must discontinue medication with the following wash out periods prior to enrollment in the trial: PUVA or UVB Therapy - 4 weeks, topical nitrogen mustard or other topical chemotherapy - 4 weeks, bexarotene capsules or other systemic biologic agent - 3 weeks washout, high dose topical steroids, topical retinoids or immunotherapy - 2 week washout with 1% topical hydrocortisone , oral steroids above 10 mg - 30 day washout, unless subject has Addison's Disease or adrenal insufficiency 8. Who are refractory to at least one of the standard therapies used to treat Stage IA, IB or IIA CTCL such as oral steroids, high-dose topical steroids, topical nitrogen mustard, Bexarotene, PUVA therapy, electron beam radiation, biological response modifiers or oral methotrexate. 9. Must be willing to abstain from therapeutic sunbathing, phototherapy, tanning beds, etc. for the duration of the study. Exclusion Criteria: 1. Who have MF (T3 cutaneous tumors or T4 exfoliative erythroderma) Stage IIB - IVB 2. Who are unable to tolerate extracorporeal volume loss i.e., severe cardiac disease/anemia 3. With deterioration of renal function who have a serum creatinine level greater than 3.0 mg/dL. 4. With lipemic plasma \>500 ng/dL, uncontrolled diabetes, history of liver damage (2.5 x normal alanine transaminase (ALT), aspartate aminotransferase (AST), porphyria, lupus, positive tests for human immunodeficiency virus (HIV) antibody, hepatitis C virus (HCV) antibody or Hepatitis B Surface Antigen, severe emotional, behavioral or psychiatric problems that, in the opinion of the investigator, would result in poor compliance with the treatment regimen, and idiosyncratic or hypersensitivity reactions to 8-methoxypsoralen compounds, heparin, or citrate. 5. On oral prednisone therapy or high potency topical steroids. 6. Who are pregnant or nursing a child.
Contact & Investigator
Larisa Geskin, MD
PRINCIPAL INVESTIGATOR
Columbia University
Frequently Asked Questions
Who can join the NCT05680558 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Cutaneous T Cell Lymphoma. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT05680558 trial and what does that mean for participants?
Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.
Is NCT05680558 currently recruiting?
Yes, NCT05680558 is actively recruiting participants. Contact the research team at ljg2145@cumc.columbia.edu for enrollment information.
Where is the NCT05680558 trial being conducted?
This trial is being conducted at New York, United States.
Who is sponsoring the NCT05680558 clinical trial?
NCT05680558 is sponsored by Columbia University. The principal investigator is Larisa Geskin, MD at Columbia University. The trial plans to enroll 74 participants.