Photopheresis in Early-stage Mycosis Fungoides
Trial Parameters
Brief Summary
The purpose of this study is to determine whether photopheresis therapy can be used to improve the clinical course of early stage cutaneous T-cell lymphoma (CTCL). Currently, photopheresis is performed as a palliative treatment for late stage CTCL. However, recent studies have demonstrated that patients with early stage CTCL may have markers in their blood which were previously observed primarily in late stage disease, such as clonal T cell populations. Considering these findings, the study aims to investigate whether photopheresis therapy may be used earlier in the disease course to produce a clinical response.
Eligibility Criteria
Inclusion Criteria: 1. Who are male or female, over the age of 18 and \<40 kg body weight with adequate veins to provide intravenous access. 2. Who are willing to adhere to the protocol and sign an Informed Patient Consent Document 3. Must not be on any other investigational device/drug treatment. 4. Who have the diagnosis of Mycosis Fungoides (MF) including a skin biopsy consistent with MF (atypical epidermotropic or folliculocentric T-cells) with appropriate staging as IA, IB or IIA: T1 or T2 (patches or plaques) with measurable lesions. 5. With IA stage must demonstrate a minor blood abnormality by morphology/laboratory assessment. 6. With IIA stage - clinically significant nodes (1.5 cm) must have lymph node biopsy showing dermatopathic nodes or no involvement. 7. Must be willing and able to discontinue concomitant medications for MF. Subjects currently taking the following drugs must discontinue medication with the following wash out periods prior to enrollment in the trial: PUVA