NCT06430554 Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability
| NCT ID | NCT06430554 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Zhongda Hospital |
| Condition | Respiratory Distress Syndrome |
| Study Type | OBSERVATIONAL |
| Enrollment | 40 participants |
| Start Date | 2024-06-08 |
| Primary Completion | 2026-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 40 participants in total. It began in 2024-06-08 with a primary completion date of 2026-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung recruitability.
Eligibility Criteria
Inclusion Criteria: 1. age ≥18 years 2. Moderate-to-severe ARDS as per the 2023 ESICM definition 3. Undergoing invasive mechanical ventilation 4. Planned prone position based on the attending physicians' decisions 5. Signed informed consent Exclusion Criteria: 1. age ≥85 years 2. Pregnancy 3. Severe hemodynamic instability (\> 30% increase in vasopressors in the last 6 hours or norepinephrine \> 0.5 µg/kg/min) 4. Clinically suspected elevated intracranial pressure (\>18 mm Hg) 5. Bronchopleural fistula 6. Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement) 7. Severe hypernatremia (\>170mmol/L) 8. Re-admission of patients already enrolled in this study, or patients who are participating in other studies
Contact & Investigator
Fengmei Guo, PhD, MD
STUDY CHAIR
Nanjing Zhongda Hospital, Southeast University
Frequently Asked Questions
Who can join the NCT06430554 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 85 Years, studying Respiratory Distress Syndrome. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06430554 currently recruiting?
Yes, NCT06430554 is actively recruiting participants. Contact the research team at fmguo2022@163.com for enrollment information.
Where is the NCT06430554 trial being conducted?
This trial is being conducted at Nanjing, China.
Who is sponsoring the NCT06430554 clinical trial?
NCT06430554 is sponsored by Zhongda Hospital. The principal investigator is Fengmei Guo, PhD, MD at Nanjing Zhongda Hospital, Southeast University. The trial plans to enroll 40 participants.