Perioperative Risk of Immunotherapy Based Neoadjuvant and Conversion Therapy for Hepatocellular Carcinoma
Trial Parameters
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Brief Summary
This study aims to retrospectively collect a cohort of participants with hepatocellular carcinoma who received immunotherapy-based neoadjuvant/translational treatment. A multi-dimensional and multi-method analysis plan will be adopted. The goal is to provide solutions for better application of neoadjuvant immunotherapy and to offer better evidence for conducting prospective clinical research on hepatocellular carcinoma.
Eligibility Criteria
Inclusion Criteria: Participants must meet all of the following conditions in order to be enrolled in this study: 1. Voluntarily participate in this study and sign an informed consent form. 2. Participants diagnosed with HCC through pathological histology/cytology or clinically diagnosed with HCC according to the Diagnosis and Treatment Guidelines for Primary Liver Cancer (2024 Edition). 3. Received immunotherapy based neoadjuvant or conversion therapy. 4. Complete recovery from surgical resection within 4 weeks prior to enrollment. 5. Child Pugh liver function rating A or B (≤ 7 points). 6. ECOG PS score was 0-1 points. 7. Expected survival time ≥ 12 weeks. 8. If suffering from hepatitis B virus (HBV) infection, it is necessary to be willing to receive antiviral treatment throughout the study period (according to the diagnostic and treatment guidelines, such as entecavir) and regularly monitor it; Hepatitis C virus (HCV) ribonucleic acid (RNA) positive subjects must receive antiviral