NCT05729646 Perioperative Chemotherapy Plus Toripalimab for dMMR Locally Advanced Gastric or Esophagogastric Junction Adenocarcinoma
| NCT ID | NCT05729646 |
| Status | Recruiting |
| Phase | Phase 2 |
| Sponsor | Yu jiren |
| Condition | Adenocarcinoma of the Stomach |
| Study Type | INTERVENTIONAL |
| Enrollment | 90 participants |
| Start Date | 2023-05-31 |
| Primary Completion | 2026-02-28 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.
This trial targets 90 participants in total. It began in 2023-05-31 with a primary completion date of 2026-02-28.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study is a prospective, multi-center, randomized controlled phase II trial to compare the efficacy of perioperative SOX plus toripalimab, toripalimab monotherapy with SOX regimen in participants with dMMR locally advanced gastric or esophagogastric junction adenocarcinoma
Eligibility Criteria
Inclusion Criteria: 1. Voluntary participation in the clinical study; fully understands and is informed of the study and has signed the Informed Consent Form (ICF). 2. Participants were ambulatory male or female. Age: ≥ 18 years and ≤ 80 years old. 3. Histopathologically confirmed gastric or esophagogastric junction adenocarcinoma. 4. Mismatch repair deficient (dMMR) adenocarcinoma, which was determined by immunohistochemistry (ICH) test of endoscopic biopsy specimen. dMMR was defined as loss of nuclear expression of one or more MMR proteins. 5. cT2-4bN+/-, M0 according to the American Joint Committee on Cancer and Union for International Cancer Control (AJCC-UICC) TNM classification for carcinoma of the stomach (8th edition). 6. Participants had Eastern Cooperative Oncology Group (ECOG) performance status scores of 0-1 within 7 days before the first dose of study treatment. 7. Life expectancy ≥ 6 months. 8. Agreement of providing baseline and surgical specimens for biomarker analysis. 9. The functions of the vital organs meet requirements as follows (within 14 days before the first dose of study treatment, meanwhile, participants had not received treatment of recombinant human thrombopoietin or granulocyte stimulating factor): 1). Hematological function# -White blood cell count (WBC): 3.5 × 10\^9/L \~12.0 × 10\^9/L -Absolute neutrophil count (ANC) ≥ 1.5 × 10\^9/L -Platelet count (PLT) ≥ 100 × 10\^9/L * Hemoglobin (Hb) ≥ 90g/L. 2). Hepatic function * Total bilirubin (TBIL) ≤ 1.5 × ULN (upper limit of normal); -Aspartate aminotransferase (AST) ≤ 2.5 × ULN; * Alanine aminotransferase (ALT) ≤ 2.5 × ULN; * Albumin (ALB) ≥ 30g/L. 3). Renal function * Creatinine (Cr) ≤ 1.5 × ULN, or creatinine clearance ≥ 60 ml / min for those with creatinine level \> 1.5 × ULN. 4). Coagulation function# * International normalized ratio (INR) ≤ 1.5; * Prothrombin time (PT) and activated partial thromboplastin time (APTT) ≤ 1.5 × ULN. 10\. Female participants of childbearing age must meet requirements: urine or serum pregnancy test must be negative within 7 days before the first dose of study treatment, and she must agree to use adequate contraception methods or keep abstinence (starting with the ICF is signed through 120 days after the last dose of toriplimab, or 180 days after the last dose of chemotherapy, whichever is longer, and should not be breastfeeding. Male participants must meet requirements: agree to use adequate contraception methods or keep abstinence (starting with the ICF is signed through 120 days after the last dose of toriplimab, or 180 days after the last dose of chemotherapy, whichever is longer). Exclusion Criteria: 1. HER2-positive status defined as either IHC score of 3+ or IHC 2+ with amplification proven by fluorescent in situ hybridization (FISH) based on pretreatment endoscopic biopsies. 2. Prior systemic therapy for treatment of gastric cancer (surgery, chemotherapy, radiotherapy, targeted therapy or immunotherapy). 3. Previous or concurrent have other active malignant tumors within the past 5 years (except for basal cell or squamous cell carcinoma of the skin, superficial bladder cancer, prostate cancer or cervical cancer or breast cancer in situ that has undergone curative therapy). 4. Participants with gastric outlet obstruction, or unable to oral take, or severe gastrointestinal bleeding. 5. Myocardial infarction within 6 months before the first dose of study treatment, uncontrolled angina, arrhythmia which need medical intervention (including but not limited to cardiac pacemaker), congestive heart failure (New York Heart Association (NYHA) class III or IV). 6. Existence of chronic diarrhea (watery diarrhea: ≥ 5 times per day). 7. Participants with active infection within 14 days before the first dose of study treatment which need medical intervention. 8. Participants with active tuberculosis. 9. Previous or concurrent diagnosed with interstitial lung disease by imaging or symptoms. 10. Any of the following test is positive: Human Immunodeficiency Virus (HIV) antibody, Hepatitis B surface Antigen (HBsAg), or Hepatitis C Virus (HCV) antibody. 11. Participants who need long-term systemic steroid therapy (\> 10 mg/d prednisone equivalent) or any other form of immunosuppressive therapy within 14 days before the first dose of study treatment or during the study period. 12. Concurrent or previous have severe allergic reaction to any antibody- based drugs. 13. Existence of any concurrent autoimmune disease, excepting participants with diabetes mellitus type I, hypothyroidism requiring only hormone replacement therapy. 14. Receive live vaccines within 28 days before the first dose of study treatment or during the study period, excepting inactivated viral vaccines for seasonal influenza. 15. Known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation. 16. Existence of systemic disease that is difficult to control despite treatment with several agents, for example, diabetes mellitus, hypertension, etc. 17. Existence of other serious physical or mental diseases or serious laboratory abnormalities that may increase the risk of participating in the study. Participants who were judged unsuitable as subjects of this trial by investigator.
Contact & Investigator
Jiren Yu
PRINCIPAL INVESTIGATOR
First Affiliated Hospital of Zhejiang University
Frequently Asked Questions
Who can join the NCT05729646 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Adenocarcinoma of the Stomach. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT05729646 trial and what does that mean for participants?
Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.
Is NCT05729646 currently recruiting?
Yes, NCT05729646 is actively recruiting participants. Contact the research team at yujr0909@zju.edu.cn for enrollment information.
Where is the NCT05729646 trial being conducted?
This trial is being conducted at Hangzhou, China, Hangzhou, China, Huzhou, China, Lishui, China and 4 additional locations.
Who is sponsoring the NCT05729646 clinical trial?
NCT05729646 is sponsored by Yu jiren. The principal investigator is Jiren Yu at First Affiliated Hospital of Zhejiang University. The trial plans to enroll 90 participants.