NCT07274189 Periodontal Health and Sodium Bicarbonate Toothpaste
| NCT ID | NCT07274189 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Plymouth |
| Condition | Periodontal Diseases |
| Study Type | INTERVENTIONAL |
| Enrollment | 100 participants |
| Start Date | 2024-12-04 |
| Primary Completion | 2026-10-20 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 100 participants in total. It began in 2024-12-04 with a primary completion date of 2026-10-20.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to determine whether sodium bicarbonate fluoride toothpaste can help maintain periodontal health in adults who have undergone non-surgical periodontal treatment. The main question it aims to answer is: Does daily use of toothpaste affect the following outcomes: clinical oral health (plaque scores, gingival bleeding scores and periodontal pocket depths), salivary biochemical markers and the oral microbiome. Outcomes measures will be recorded at 0,3, and 6 months, during which time participants will receive either the treatment or placebo toothpaste and undergo oral hygiene instruction and PMPR over 6 months.
Eligibility Criteria
Inclusion Criteria: * Adult participants \>18 years, of any gender will be recruited. Exclusion Criteria: * Full dentures * Diabetics * Cancer diagnosis * Pregnancy * Use of antibiotics (\<3 months prior to participation) * Use of antibacterial mouthwash * Inorganic nitrates taken less than 4 weeks before the study * Immunosuppressants taken less than 4 weeks before the study * BPE's score of less than 3, and or/ BPE score of more than two 4's.
Contact & Investigator
Zoe Brookes, BDS, MJDF, PCHE, SFHEA, PhD
PRINCIPAL INVESTIGATOR
University of Plymouth
Frequently Asked Questions
Who can join the NCT07274189 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Periodontal Diseases. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07274189 currently recruiting?
Yes, NCT07274189 is actively recruiting participants. Contact the research team at zoe.brookes@plymouth.ac.uk for enrollment information.
Where is the NCT07274189 trial being conducted?
This trial is being conducted at Plymouth, United Kingdom.
Who is sponsoring the NCT07274189 clinical trial?
NCT07274189 is sponsored by University of Plymouth. The principal investigator is Zoe Brookes, BDS, MJDF, PCHE, SFHEA, PhD at University of Plymouth. The trial plans to enroll 100 participants.