← Back to Clinical Trials
Recruiting NCT06691230

PeRfusiOn Post tHrombEcTomy (PROPHET)

◆ AI Clinical Summary
Plain-language summary for patients

Trial Parameters

Condition Stroke, Acute, Ischemic
Sponsor Insel Gruppe AG, University Hospital Bern
Study Type OBSERVATIONAL
Phase N/A
Enrollment 279
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2024-11-01
Completion 2027-11-30

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

Brief Summary

Endovascular mechanical thrombectomy is the standard of care for treating patients with a large-vessel occlusion acute ischemic stroke. However, in more than half of these patients, remaining distal vessel occlusions limit the benefit of this therapy. Currently the detection of residual vessel occlusions and the decision for further treatment by the operator is based on the 2D digital subtraction angiography (DSA) images. However, this technique has several limitations. Recently, a new imaging technique, with the possibility to acquire 3D time-resolved perfusion images directly in the operating room was introduced (the flat-panel detector computed tomography perfusion imaging, FDCTP). It can overcome the spatial limitations of 2D DSA, but the details on clinical validation and utility of FDCTP are currently lacking.

Eligibility Criteria

Inclusion Criteria: * Informed consent as documented by a signature * The patients received mechanical thrombectomy or there was the intention to perform endovascular treatment, but only diagnostic angiography was performed. * Patients received FDCTP as clinically indicated by the treating physician. Exclusion Criteria: * Inability to give consent due to insufficient knowledge of the project language * Inability to follow the clinically indicated visit at 90 days after the index stroke (e.g. patients living abroad).

Related Trials

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology
}