Perfusion Imaging Evaluation for Ischemic Stroke on 6-24 Hours Undergoing Endovascular Thrombectomy
Trial Parameters
Brief Summary
This study aims to evaluate the hypothesis that thrombectomy devices plus medical management leads to superior clinical outcomes in acute ischemic stroke patients at 90 days as compared to medical management alone in appropriately selected subjects with the Target Mismatch Profile and an MCA (M1 and M2 segment) or ICA occlusion or BA who have endovascular thrombectomy initiated between 6-24 hours after last seen well.
Eligibility Criteria
Inclusion Criteria: Clinical Inclusion Criteria: 1. Clinical signs and symptoms consistent with the diagnosis of an acute ischemic stroke 2. Age ≥18 years 3. NIHSS ≥ 6 4. Endovascular thrombectomy can be initiated (femoral puncture) between 6 and 24 hours after time last know well 5. No significant pre-stroke disability (pre-stroke mRS must be ≤ 3 ) 6. Patient/Legally Authorized Representative has signed the Informed Consent form Imaging Inclusion Criteria: 1. ICA or MCA-M1 or MCA-M2 or BA occlusion (carotid occlusions can be cervical or intracranial with or without tandem MCA lesions) as evidenced by MRA or 4D-CTA 2. Target Mismatch Profile on CT perfusion or MR perfusion: ischemic core volume is ≤ 70 ml, mismatch ratio is \>/= 1.2 ) Exclusion Criteria: Clinical Exclusion Criteria: 1. Other serious, advanced, or terminal illness (investigator judgment) or life expectancy is less than 90 days 2. Subject with a co-morbid disease or condition that would confound the neurological and func