NCT05357456 Performances on Cognitive Functions and Brain Function and Follow-up After Different Treatments in Patients With Autonomous Cortisol Secretion: a Single-center, Prospective, Observational Study
| NCT ID | NCT05357456 |
| Status | Recruiting |
| Phase | — |
| Sponsor | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School |
| Condition | Autonomous Cortisol Secretion |
| Study Type | OBSERVATIONAL |
| Enrollment | 62 participants |
| Start Date | 2021-10-01 |
| Primary Completion | 2024-10-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 62 participants in total. It began in 2021-10-01 with a primary completion date of 2024-10-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a single center, prospective, observational study to explore and evaluate the differences on cognitive function and brain function by functional-MRI in autonomous cortisol secretion patients, and the different treatments methods on the cognitive function and brain function in patients with autonomous cortisol secretion
Eligibility Criteria
Inclusion Criteria: * age 20-65 years; * ≥ 6 years of education； * right-handed; * complete entire cognitive function tests; * adrenal lesions ≥ 1 cm in diameter; * patients with non-functioning adrenal adenomas; * patients with autonomous cortisol secretion. Exclusion Criteria: * \< 6 years of education; * age \< 20 years or \> 65 years; * maximum diameter of AI \<1cm; * active malignancies; * with a history of thyroid disease; * with a history of acute infection in the last month; * central nervous system diseases, including brain trauma, intracranial hemorrhage, acute cerebral infarction, etc; * contraindications of MRI examination: such as implantation of metal prosthesis in vivo, claustrophobia, etc; * adrenal tuberculosis; * suspected or diagnosed adrenocortical carcinoma; * unable to complete entire cognitive function tests; * current use of steroids or any drugs known to alter steroid synthesis or metabolism in the previous 3 months; * clinical Cushing syndrome; * Cushing disease; * primary hyperaldosteronism; * pheochromocytoma; * severe impairment of heart, liver, kidney and other organs; * pregnant and lactating women
Contact & Investigator
Dalong Zhu, MD,PhD
PRINCIPAL INVESTIGATOR
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Frequently Asked Questions
Who can join the NCT05357456 clinical trial?
This trial is open to participants of all sexes, aged 20 Years or older, up to 65 Years, studying Autonomous Cortisol Secretion. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05357456 currently recruiting?
Yes, NCT05357456 is actively recruiting participants. Contact the research team at zhudalong@nju.edu.cn for enrollment information.
Where is the NCT05357456 trial being conducted?
This trial is being conducted at Nanjing, China.
Who is sponsoring the NCT05357456 clinical trial?
NCT05357456 is sponsored by The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School. The principal investigator is Dalong Zhu, MD,PhD at The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School. The trial plans to enroll 62 participants.