NCT07584187 PERCEPTION - Super-Early Neuroprognostication in eCPR Patients
| NCT ID | NCT07584187 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Medical University of Vienna |
| Condition | Resuscitation |
| Study Type | OBSERVATIONAL |
| Enrollment | 45 participants |
| Start Date | 2026-05-12 |
| Primary Completion | 2028-06 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 45 participants in total. It began in 2026-05-12 with a primary completion date of 2028-06.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Background Extracorporeal cardiopulmonary resuscitation (eCPR) is a rescue therapy for a selected group of patients. Extracorporeal membrane oxygenation (ECMO) is initiated to bypass the cardiac system and bridge time to definitive treatment of the cardiac arrest (CA) origin. eCPR treatment is very time-critical and, if indicated, should be initiated as early as possible. Patient selection for this highly specific treatment is challenging and relies on numerous factors. In the following phase of intensive care treatment, neuroprognostication is performed. However, following current guidelines, this is only recommended 72hours after CA. Once ECMO is initiated, a complex intensive care treatment is expected, without a guarantee for full neurological recovery. There is a recognized clinical need for more precise selection criteria, alongside predictive values, to enable earlier, reliable neuroprognostication. Aim This study aims to investigate whether super-early neuroprognostication before ECMO initiation is feasible. Super-early neuroprognostication will be performed using automated pupillometry and cerebral near-infrared spectroscopy (cNIRS) before ECMO initiation. Methods Patients evaluated for eCPR treatment at the Department of Emergency Medicine will be included in this study. By a study member not involved in clinical treatment, cNIRS and automated pupillometry will be performed before ECMO initiation and at predefined intervals: 10-20 minutes after ECMO Initiation, 1 hour (±15 minutes), 2 hours (±15 minutes), and 3 hours (±15 minutes). Follow-up measurements will be taken 24 hours (± 6 hours), 48 hours (± 6 hours), and 72 hours ± 6 hours after ECMO initiation. The secondary objective is to interpret the collected data regarding outcome parameters.
Eligibility Criteria
Inclusion Criteria: * All patients ≥ 18 years evaluated for eCPR treatment at the Department of Emergency Medicine Exclusion Criteria: * Return of spontaneous circulation before ECMO initiation. * Anatomical infeasibility for measurement, including but not limited to: * Severe facial trauma or deformity preventing the placement of the automated pupillometry device. * Scalp injuries, dressings, or conditions that interfere with the correct positioning of near-infrared spectroscopy (NIRS) sensors. * Pre-existing ocular conditions that preclude reliable pupillometry (e.g., enucleation, opaque cornea, or severe anisocoria unrelated to neurological status).
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07584187 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Resuscitation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07584187 currently recruiting?
Yes, NCT07584187 is actively recruiting participants. Contact the research team at juergen.grafeneder@meduniwien.ac.at for enrollment information.
Where is the NCT07584187 trial being conducted?
This trial is being conducted at Vienna, Austria.
Who is sponsoring the NCT07584187 clinical trial?
NCT07584187 is sponsored by Medical University of Vienna. The trial plans to enroll 45 participants.