NCT06836830 PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest
| NCT ID | NCT06836830 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Muehlenkreiskliniken, MKK |
| Condition | Ventilation Therapy |
| Study Type | INTERVENTIONAL |
| Enrollment | 600 participants |
| Start Date | 2025-06-01 |
| Primary Completion | 2026-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 600 participants in total. It began in 2025-06-01 with a primary completion date of 2026-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.
Eligibility Criteria
Inclusion Criteria: * Adults \>= 18 years * non-traumatic OHCA * mechanical ventilation via airway device Exclusion Criteria: * Patients \< 18 years, * traumatic cause of OHCA, * no cardiac arrest, withholding of resuscitation (e.g. Do-Not-Resuscitate orders)
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06836830 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Ventilation Therapy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06836830 currently recruiting?
Yes, NCT06836830 is actively recruiting participants. Contact the research team at gerrit.jansen@muehlenkreiskliniken.de for enrollment information.
Where is the NCT06836830 trial being conducted?
This trial is being conducted at Gütersloh, Germany, Minden, Germany, Osnabrück, Germany.
Who is sponsoring the NCT06836830 clinical trial?
NCT06836830 is sponsored by Muehlenkreiskliniken, MKK. The trial plans to enroll 600 participants.