NCT06705257 PEEP FOR LUNG RECRUITMENT IN PRETERM INFANTS-EIT STUDY
| NCT ID | NCT06705257 |
| Status | Recruiting |
| Phase | — |
| Sponsor | South Tees Hospitals NHS Foundation Trust |
| Condition | PreTerm Neonate |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2025-06-15 |
| Primary Completion | 2026-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 30 participants in total. It began in 2025-06-15 with a primary completion date of 2026-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Babies born early (under 32 weeks) are at risk of developing lung problems after birth. A major reason for this is that the lungs are not fully developed. Lungs of preterm babies will often collapse in between breathing due to lung immaturity. Applying gentle pressure, using nasal device through their nostril or through the breathing tube helps to prevent this lung collapse. This would help in air-oxygen going to lungs and also makes the babies breathing more comfortable. This gentle pressure is medically called as PEEP/CPAP and could be delivered by breathing machine (ventilator) and CPAP machine, collectively called as "continuous distending pressure (CDP)". Those babies breathing on their own and receiving inadequate CDP would need more breathing support by placing them on breathing machine (ventilator). The longer the baby receives breathing machine support, higher chance of lung injury . Preterm infants who are already on breathing machine, providing sub optimal PEEP/CPAP could also lead to lung damage. Providing optimal PEEP/CPAP could prevent these negative outcomes. Currently there is not enough evidence to suggest optimal PEEP/CPAP in preterm infants. Neonatal units all around the world uses PEEP/CPAP ranging from 4 to 10cm H20 based on their unit practice. Currently available investigations provide limited one time information (e.g. Chest X-ray) regarding whether baby is receiving optimal PEEP/CPAP. Electrical Impedance Tomography (EIT) is a new technology which could provide better information regarding the pressure delivered. Also, this device would provide continuous information as if the clinicians are doing continuous chest X-ray but without any radiation. In this study, the team will assess the effect of different levels of PEEP/CPAP (4 to 10cm H20) on prevention of lung collapse using EIT. This would be studied in premature infants who are on breathing machine support and CPAP machine support.
Eligibility Criteria
Inclusion criteria 1. Gestational age \<32 weeks based on mother's last menstrual period or first trimester ultrasound dating. 2. Receiving either CPAP or mechanical ventilation respiratory support. 3. Informed written consent from one of the parents. 4. Within the first two weeks of life. Investigators pragmatically chose this period, as there could be considerable lung injury after the first two weeks of life, making it difficult to test our hypothesis. Also, this time period would allow parents to settle down with their stressful preterm delivery and investigators could approach anytime within the first two weeks of life. Exclusion criteria 1. Major congenital malformations including congenital lung disease and congenital heart disease as ascertained by the medical team. 2. Infants diagnosed with pneumothorax i. 3. Receiving high frequency mechanical ventilation. 4. Infants with concerns of skin integrity.
Contact & Investigator
Jackie Mitchell
STUDY DIRECTOR
South Tees NHS foundation trust
Frequently Asked Questions
Who can join the NCT06705257 clinical trial?
This trial is open to participants of all sexes, aged 22 Weeks or older, up to 32 Weeks, studying PreTerm Neonate. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06705257 currently recruiting?
Yes, NCT06705257 is actively recruiting participants. Contact the research team at pkannanloganathan@nhs.net for enrollment information.
Where is the NCT06705257 trial being conducted?
This trial is being conducted at Middlesbrough, United Kingdom.
Who is sponsoring the NCT06705257 clinical trial?
NCT06705257 is sponsored by South Tees Hospitals NHS Foundation Trust. The principal investigator is Jackie Mitchell at South Tees NHS foundation trust. The trial plans to enroll 30 participants.