Patient-Centered Assessment of Symptoms and Outcomes
Trial Parameters
Eligibility Fast-Check
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Brief Summary
Background: The cause of fatigue is not well understood. It can be felt differently by different people. Some people think there are different types of fatigue, with different causes. Researchers think a therapy to treat one type of fatigue in one condition should be able to treat that type of fatigue in other conditions. Objective: To understand the types of fatigue. Eligibility: Adults 18 and older who have felt fatigue for more than a month, and non-fatigued adults Design: Participants will be screened with a physical exam, their medical history, a vision test, and blood and urine tests. Participants will begin to track the foods they eat. This study will involve up to 10 visits. Each visit will last no more than 4 hours. In Stage 1, participants will have an interview, fill out questionnaires, and play computer games. They will take walking and handgrip tests. They will give blood, urine, and saliva samples. They will wear a wrist monitor at home for 7 days and write down their activities. They will be put into a group: fatigue or non-fatigued control. In Stage 2, participants will answer questionnaires and give a blood sample. They will have heart tests. They may take exercise and lung function tests that include wearing a nose clip. They may have an optional brain MRI: They may wear an electrode cap on their head during the scan to measure brain activity. They will lie on table that slides into a cylinder. They may perform tasks in the scanner. After the study, participants might be contacted about other studies.
Eligibility Criteria
* INCLUSION CRITERIA: All Participants (including returning participants) * Adult participants aged \>= 18 years at the time of enrollment. * Able to provide written informed consent. * Willing and able to complete study procedures. Fatigued Participants -In addition to the above, must experience fatigue for more than a month. Healthy Volunteers for the fMRI study * Right handed * Not taking any prescribed medications for chronic medical conditions * Not diagnosed with any chronic medical condition EXCLUSION CRITERIA: Exclusion from study entry: * Not fluent in English. * Have medical health issues that create additional and substantial adverse risks related to study procedures. Medical examples are the acute complications of medical disease, such as unstable hypertension, diabetic ketoacidosis, symptomatic hyperthyroidism, and unstable angina. * Have a psychiatric condition that prevents participant from being able to reliably report the fatigue experience (e.g., a psychotic disorder