NCT05300971 Passive Heat Therapy for Lowering Systolic Blood Pressure and Improving Vascular Function in Mid-life and Older Adults
| NCT ID | NCT05300971 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Colorado, Boulder |
| Condition | Aging |
| Study Type | INTERVENTIONAL |
| Enrollment | 150 participants |
| Start Date | 2022-08-01 |
| Primary Completion | 2027-11-01 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
This study aims to determine the effects of \~12 weeks of repeated hot water immersion ("heat therapy") vs. thermoneutral water immersion on blood pressure and vascular function in late middle-life to older (≥40 years) adults. The study also aims to determine the effects of \~12 weeks of heat therapy on fluid cognitive and cerebrovascular function.
Eligibility Criteria
Inclusion Criteria: * Able to provide informed consent (no clinical diagnosis of dementia or related diseases AND mini mental state exam score \>20). * Willing to accept random assignment to intervention. * Aged 40+ years. * Premenopausal women must not be pregnant (confirmed by urine pregnancy test). * Casual systolic blood pressure 115-159 mmHg. * Sufficiently healthy to undergo heat stress, as determined by the CTRC physician Dr. Wolfe and physician of record Dr. Chonchol based on medical history, physical exam, blood chemistries, and 12-lead ECG at rest and during the graded exercise test. Subjects with established clinical diseases may participate so long it is not determined that heat therapy could be detrimental to their health (determined case-by-case, but examples of subjects who may be excluded include those currently undergoing chemotherapy treatment or chronic kidney disease patients requiring dialysis). * Ability to refrain from the use of dietary supplements, anti-inflamm