NCT06644066 Partial Pressure of Oxygen Control Method in Identification of Intersegmental Plane
| NCT ID | NCT06644066 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Tang-Du Hospital |
| Condition | Lung Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2024-05-01 |
| Primary Completion | 2024-07-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2024-05-01 with a primary completion date of 2024-07-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
In recent years, an increasing number of pulmonary nodules have been detected through CT screening. The traditional surgical method for lung cancer is lobectomy combined with lymph node dissection. However, recent studies have demonstrated that sublobar resection for early non-small cell lung cancer (NSCLC) is an effective alternative with the additional benefit of preserving more pulmonary function. However, it also faces many problems, the most prominent of which is the rapid and accurate identification of the intersegmental plane (ISP) during surgery. The modified inflation-deflation method for identifying the ISP is the most commonly used method in anatomical sublobar resection. Nevertheless, the lengthy waiting periods and the lack of clear delineation represent significant challenges in clinical practice. The Partial pressure of Oxygen Control method facilitates the efficient determination of the ISP by reducing the oxygen inhalation concentration and ventilator ventilation time during surgery. This results in a reduced PaO2 in arterial blood, thereby accelerating the rapid appearance of the ISP. Thus, the investigators conducted a prospective, randomized, controlled trial to ascertain whether the oxygen partial pressure control method affects the occurrence time of the ISP and PaO2 during one-lung ventilation, in comparison to the modified inflation-deflation method. Furthermore, the objective was to confirm the safety and efficacy of Partial pressure of Oxygen Control method.
Eligibility Criteria
Inclusion Criteria: 1. Between the ages of 18 and 75; 2. Gender unlimited; 3. Eastern Cooperative Oncology Group（ECOG） Performance status（PS） score 0-1 points; 4. Thin slice CT indicates that the maximum tumor diameter is ≤ 2.0cm and 0 ≤ CTR\<1.0; （Consolidation Tumor Ratio，CTR） 5. Those who voluntarily sign the informed consent form for research can comply with the requirements of the research visit plan and other protocols. Exclusion Criteria: 1. Individuals with a history of lung surgery in the past; 2. Patients with interstitial pneumonia, pulmonary alveoli, pulmonary fibrosis, or severe emphysema; 3. Those who undergo chest surgery due to various reasons or change the surgical plan during the operation; 4. The subjects do not understand, cooperate or refuse to sign the informed consent form regarding the research protocol.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06644066 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Lung Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06644066 currently recruiting?
Yes, NCT06644066 is actively recruiting participants. Contact the research team at yanxiaolong@fmmu.edu.cn for enrollment information.
Where is the NCT06644066 trial being conducted?
This trial is being conducted at Xi'an, China.
Who is sponsoring the NCT06644066 clinical trial?
NCT06644066 is sponsored by Tang-Du Hospital. The trial plans to enroll 60 participants.
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.