This study examines pain in children with juvenile idiopathic arthritis (JIA), the most common type of arthritis affecting children. JIA causes joint swelling, stiffness, and pain that can significantly impact children's daily activities and quality of life. Researchers are working to better understand the mechanisms of pain in JIA to improve treatment approaches.
Key Objective: This trial aims to improve understanding of pain in juvenile arthritis, which could lead to better pain management and treatment strategies for affected children.
Who to Consider: Children diagnosed with juvenile idiopathic arthritis who experience joint pain and are interested in contributing to research that may improve pain management for future patients should consider enrolling.
Trial Parameters
Brief Summary
Juvenile idiopathic arthritis (JIA) is the most common rheumatologic disease in children. The main symptoms of JIA, which are often the primary focus of treatment, include joint swelling, stiffness, and tenderness. Additional symptoms can include malaise, fatigue, and pain. However, the exact mechanisms contributing to pain are not yet fully understood. Participants will complete a 2.5-hours study session. In the study session, psychophysical assessments of thermal and pressure stimuli will be performed. In addition, demographic, social, pubertal maturation, and behavioral and psychological factors will be collected via questionnaires. A saliva sample and/or blood draw may occur for the analysis of various immune factors and sex hormones. If a joint aspiration is done as part of their standard of care, we will request a sample of the synovial fluid for analyses of immune, hormonal and/or genetic factors. Participants will have the option to participate in additional optional follow-up study visits (every 3 months, up to 1 year) and to complete monthly surveys asking about their juvenile arthritis.
Eligibility Criteria
Inclusion Criteria: 1. Age between 9-17 2. Males and females 3. English speakers 4. Able to complete surveys and understand study instructions 5. Juvenile arthritis group: diagnosed or suspected of juvenile arthritis 6. Control group: healthy Exclusion Criteria: 1. Pregnancy or breastfeeding 2. (Control Group) Diagnosed with a chronic pain condition 3. (Control Group) Diagnosed with psychiatric condition including ADHD, anxiety, depression, etc.