Pain After Removal of Mandibular Third Molars With or Without Advanced Platelet-rich Fibrin
Trial Parameters
Brief Summary
Pain is the most common complication following surgical removal of an impacted mandibular third molar. Several risk factors may increase the intensity and duration of pain following removal of mandibular third molars. Acute postoperative pain can transcript into postoperative chronic pain without an explainable reason or a specific risk factor. The use of advanced platelet-rich fibrin in the extraction socket following surgical removal of mandibular third molar have diminished the intensity and duration of acute postoperative pain and facilitated improved wound healing. The objective of the present study is therefore to identified specific risk factors and predictors for developing postoperative chronic pain following surgical removal of mandibular third molars with or without advanced platelet-rich fibrin applied in the extraction socket using epigenetic modulation.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years. * Presence of a semi- or fully impacted mandibular third molar. * Indication for surgical removal of mandibular third molar. Exclusion Criteria: * Patients suffering from chronic pain syndrome. * Patients in need of daily analgetic. * Pregnancy. * Psychiatric problems or unrealistic expectations.