NCT06268431 Oxytocin Rest to Reduce Cesarean Delivery
| NCT ID | NCT06268431 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Christiana Care Health Services |
| Condition | Prolonged Labor |
| Study Type | INTERVENTIONAL |
| Enrollment | 350 participants |
| Start Date | 2024-03-19 |
| Primary Completion | 2026-02-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 350 participants in total. It began in 2024-03-19 with a primary completion date of 2026-02-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Prolonged labor is usually managed with continuous oxytocin infusion. "Oxytocin rest" has been proposed as a strategy to resolve protracted labor in patients who have received continuous oxytocin without progress. This strategy involves discontinuing oxytocin then restarting infusion after a period of time, under the theory that washout of the oxytocin receptor will strengthen uterine contractions to improve labor progress. "Oxytocin rest" is performed on labor and delivery units across the United States. Yet, there is no randomized or prospective data to support the practice. The purpose of this study is to assess whether oxytocin rest of 60 minutes in patients with prolonged labor reduces risk for cesarean delivery.
Eligibility Criteria
Inclusion Criteria: * ≥18 years of age * Singleton gestation in vertex presentation * ≥36 weeks gestation * Prolonged latent labor, defined as cervical dilation \<6cm after ≥8 hours since rupture of membranes and on continuous oxytocin Exclusion Criteria: * Not meeting the above criteria * Any contraindication to continuous oxytocin at time of randomization * Cesarean section anticipated by the clinical team at time of randomization (for any reason excepting labor dystocia) * \>18 hours between rupture of membranes and randomization * Known intraamniotic infection at randomization * Fetal demise * Any contraindication to vaginal delivery * Maternal eclampsia
Contact & Investigator
Teresa C Logue
PRINCIPAL INVESTIGATOR
Christiana Care Health Services
Frequently Asked Questions
Who can join the NCT06268431 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 55 Years, studying Prolonged Labor. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06268431 currently recruiting?
Yes, NCT06268431 is actively recruiting participants. Contact the research team at teresa.logue@christianacare.org for enrollment information.
Where is the NCT06268431 trial being conducted?
This trial is being conducted at Newark, United States.
Who is sponsoring the NCT06268431 clinical trial?
NCT06268431 is sponsored by Christiana Care Health Services. The principal investigator is Teresa C Logue at Christiana Care Health Services. The trial plans to enroll 350 participants.