| NCT ID | NCT07742124 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospital, Basel, Switzerland |
| Condition | Postmenopausal |
| Study Type | OBSERVATIONAL |
| Enrollment | 30 participants |
| Start Date | 2026-08-20 |
| Primary Completion | 2027-06-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 30 participants in total. It began in 2026-08-20 with a primary completion date of 2027-06-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The aim of the present study is to assess whether cumulative endogenous neurophysin I secretion over one month differs between premenopausal and postmenopausal women. Using repeated measurements of neurophysin-I (NP-I, equimolar surrogate marker of oxytocin) across defined physiological time points, this study investigates oxytocin system regulation under cyclic and non-cyclic hormonal conditions. The primary hypothesis is that cumulative NP-I release, expressed as the area under the curve (AUC) is lower in the postmenopausal group compared to the premenopausal group.
Eligibility Criteria
Inclusion Criteria: * Female sex at birth * Age ≥18 years Premenopausal group: • Premenopausal women aged 18-35 years with regular menstrual cycles (21-35 days) for ≥3 months prior to study entry Postmenopausal group: • Postmenopausal women ≥2 years of postmenopause (i.e. 3 years since last menstrual period (LMP), with menopause defined as ≥ 12 months of amenorrhea) Exclusion Criteria: * Pregnancy or breastfeeding * Use of hormonal contraception or hormone replacement therapy within the last 3 months * Known endocrine disorders affecting the hypothalamic-pituitary-gonadal axis * Use of medications * Severe depression (BDI score \> 28 points), any other severe psychiatric illness or acute medical disease * Inability to comply with study procedures * Participation in a trial with investigational drugs within the last 30 days
Contact & Investigator
Mirjam Christ-Crain, Prof. Dr. med.
PRINCIPAL INVESTIGATOR
University Hospital Basel Endocrinology, Diabetes and Metabolism
Frequently Asked Questions
Who can join the NCT07742124 clinical trial?
This trial is open to female participants only, aged 18 Years or older, studying Postmenopausal. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07742124 currently recruiting?
Yes, NCT07742124 is actively recruiting participants. Contact the research team at Mirjam.Christ-Crain@usb.ch for enrollment information.
Where is the NCT07742124 trial being conducted?
This trial is being conducted at Basel, Switzerland.
Who is sponsoring the NCT07742124 clinical trial?
NCT07742124 is sponsored by University Hospital, Basel, Switzerland. The principal investigator is Mirjam Christ-Crain, Prof. Dr. med. at University Hospital Basel Endocrinology, Diabetes and Metabolism. The trial plans to enroll 30 participants.