Ovarian Hyperstimulation and Fibrin Clot Properties.
Trial Parameters
Brief Summary
The impact evaluation of ovarian hyperstimulation on coagulation and fibrinolysis in infertile women. Comparative analysis between different ovarian stimulation protocols on thrombin formation and efficiency of fibrinolysis in women diagnosed with infertility.
Eligibility Criteria
Inclusion Criteria: * infertility defined based on the WHO 2010 criteria Exclusion Criteria: * ovarian involvement * oral contraceptives use within previous 3 months * dienogest therapy within 3 months until ART * thrombotic events in the medical history * severe hypertension * diabetes mellitus * the presence of known VTE risk factors, including obesity, recent major surgery with prolonged immobilization or trauma, * deficiency of antithrombin, protein C or protein S, * antiphospholipid syndrome, * known malignancy, * any chronic inflammatory diseases (e.g. rheumatoid arthritis) * advanced chronic renal disease (estimated glomerular filtration rate \[eGFR\] \<30 ml/min), * international normalized ratio (INR) more than 1.2 at the day of blood draw * pregnancy.