Trial Parameters
Brief Summary
This study involves collecting exhaled breath containing hundreds of volatile organic compounds (VOCs) that are present in very low quantity (parts per billion). VOCs in the exhaled gase carry information to indicate individual's risk for Postoperative Delirium and its severity. Our long-term objectives are to identify breathomic patterns for prediction, early detection, and stratification of POD during pre- and post-operative phases.
Eligibility Criteria
Inclusion Criteria: * Participants who are 65 years old or older with a spine surgery for at least 2 segments of spine * Participants who are anticipated to be hospitalized for 2 days or longer Exclusion Criteria: * Severe cardiovascular, respiratory, liver, kidney, or central nervous system * Diseases and having a life span of less than 3 months * A history of major neurological diseases and psychiatric illness other than AD or ADRD * Alcoholism or drug dependence * Previous inclusion in this study * Difficulty with follow-up or poor compliance serious hearing and vision impairment that affects regular conversation and reading